School of Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China.
J Control Release. 2023 Jan;353:327-336. doi: 10.1016/j.jconrel.2022.11.050. Epub 2022 Dec 6.
Tumor-derived exosomes (TDEs) are the particular communicator and messenger between tumor cells and other cells containing cancer-associated genetic materials and proteins. And TDEs who are also one of the important components consisting of the tumor microenvironment (TME) can reshape and interact with TME to promote tumor development and metastasis. Moreover, due to their long-distance transmission by body fluids, TDEs can facilitate the formation of pre-metastatic niche to support tumor colonization. We discuss the main characteristics and mechanism of TDE-mediated tumor metastasis by reshaping TME and pre-metastatic niche as well as the potential of TDEs for diagnosing tumor and predicting future metastatic development.
肿瘤来源的外泌体（TDEs）是肿瘤细胞与其他含有癌相关遗传物质和蛋白质的细胞之间的特殊通讯者和信使。而且，TDEs 也是肿瘤微环境（TME）的重要组成部分之一，它们可以重塑和相互作用于 TME，促进肿瘤的发展和转移。此外，由于它们可以通过体液进行长距离传播，TDEs 可以促进前转移龛的形成，以支持肿瘤定植。我们讨论了 TDE 介导的肿瘤转移通过重塑 TME 和前转移龛的主要特征和机制，以及 TDE 用于诊断肿瘤和预测未来转移发展的潜力。
