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复杂早期妊娠问题——剖宫产瘢痕妊娠的安全服务提供

Safe Service Delivery of a Complex Early Pregnancy Problem: Caesarean Scar Pregnancy.

作者信息

Fourie Hanine, El-Zibdeh Ahmad, Heppell Victoria, Granne Ingrid, Lim Lee Nai, Supramaniam Prasanna Raj

机构信息

John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, UK.

Early Pregnancy Assessment Unit, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.

出版信息

J Clin Med. 2022 Nov 29;11(23):7063. doi: 10.3390/jcm11237063.

Abstract

Caesarean Scar Pregnancy (CSP) is an ectopic pregnancy with implantation into the niche of the uterine scar. We aimed to describe the local management of consecutive cases of CSP to develop a standard operating procedure (SOP). Between December 2019 and June 2022, there were 19,100 maternities. Of these, 23 were CSPs in 19 patients. Median BMI was 29 (range 20.5-52), median number of Caesarean deliveries (CS) was 2 (range 1-4) and 7/23 (30%) were cigarette smokers. At diagnosis, 9/23 were live pregnancies, 3/23 were retained products of conception (RPOC), 9/23 were pregnancies of uncertain viability (PUV), and 2/23 were non-viable. In six, the initial management was expectant, surgical suction evacuation with transrectal ultrasound guidance in 16, and one had a hysterectomy. The median blood loss was 100 mL (range 50-2000 mL). Two patients (9%) required a blood transfusion. Median hospital stay was 1 day (range 0-4). At follow-up after 10 weeks, no patients had an ongoing haematoma, and one had significant RPOC electing hysterectomy. Eight women were known to have 9 subsequent pregnancies (recurrent CSP = 4, livebirth = 2, miscarriage = 2, tubal ectopic = 1). Outcomes as rated by low blood loss, short hospital stay, and rare need for further intervention were favorable. Factors associated included prompt ultrasonographic diagnosis, availability of transrectal ultrasound guided surgery, and specialist follow-up, which form the basis of the SOP.

摘要

剖宫产瘢痕妊娠(CSP)是一种异位妊娠,孕囊着床于子宫瘢痕处。我们旨在描述一系列CSP病例的局部治疗方法,以制定标准操作规程(SOP)。2019年12月至2022年6月期间,共有19100例产妇,其中19例患者发生了23例CSP。体重指数(BMI)中位数为29(范围20.5 - 52),剖宫产次数中位数为2次(范围1 - 4次),23例中有7例(30%)为吸烟者。诊断时,23例中有9例为活胎妊娠,3例为稽留流产(RPOC),9例为妊娠存活情况不明(PUV),2例为胚胎停育。6例患者最初采用期待治疗,16例在经直肠超声引导下行手术清宫,1例行子宫切除术。术中失血中位数为100 mL(范围50 - 2000 mL)。2例患者(9%)需要输血。住院时间中位数为1天(范围0 - 4天)。10周后随访时,无患者存在持续性血肿,1例有明显的RPOC并选择行子宫切除术。已知8名女性后续有9次妊娠(复发性CSP = 4次,活产 = 2次,流产 = 2次,输卵管异位妊娠 = 1次)。低失血量、短住院时间以及罕见的进一步干预需求等结果表明治疗效果良好。相关因素包括超声检查及时诊断、经直肠超声引导手术的可行性以及专科随访,这些构成了SOP的基础。

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