Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China.
Department of Endocrinology, Chongming Hospital Affiliated to Shanghai University of Health & Medicine Sciences (Chongming Branch of Xinhua Hospital), 25 Nanmen Road, Shanghai 202150, China.
Nutrients. 2022 Nov 24;14(23):5001. doi: 10.3390/nu14235001.
We aimed to investigate the associations between maternal serum aspartame/sucralose levels and metabolic health during pregnancy.
A nested population-based case-control study was conducted in 109 women with and without gestational diabetes mellitus (GDM). Serum aspartame and sucralose levels were assessed using an ultraperformance liquid chromatography coupled to a tandem mass spectrometry system.
We detected the presence of circulating aspartame and sucralose in all participants at fasting. No differences in serum aspartame or sucralose levels were observed between GDM and non-GDM groups. In the fully-adjusted linear regression models, serum aspartame levels were positively associated with insulin resistance index, total cholesterol, and LDL cholesterol. In the fully-adjusted logistic regression models, higher serum aspartame levels were positively associated with elevated HbA1c, insulin resistance, hypercholesterolemia, and hyper-LDL cholesterolemia. In the GDM group, the significant associations between higher serum aspartame levels and elevated HbA1c, insulin resistance, and hypo-HDL cholesterolemia persisted, while positive associations were found between higher serum aspartame levels and insulin resistance and hyper-LDL cholesterolemia in the non-GDM group. Serum sucralose levels were negatively associated with HbA1c.
The study found that maternal serum aspartame levels were positively associated with insulin resistance index, total cholesterol, and LDL cholesterol during pregnancy. This finding provides the different effects of specific NNS on metabolic health during pregnancy.
本研究旨在探讨母体血清中天冬甜素/三氯蔗糖水平与妊娠期代谢健康之间的关系。
本研究采用巢式病例对照研究设计，纳入了 109 例妊娠期糖尿病（GDM）患者和 109 例非 GDM 患者。采用超高效液相色谱-串联质谱法检测血清中天冬甜素和三氯蔗糖的水平。
本研究在所有空腹参与者的血清中均检测到了天冬甜素和三氯蔗糖的存在。GDM 组和非 GDM 组之间的血清天冬甜素和三氯蔗糖水平无差异。在完全校正的线性回归模型中，血清中天冬甜素水平与胰岛素抵抗指数、总胆固醇和 LDL 胆固醇呈正相关。在完全校正的逻辑回归模型中，较高的血清天冬甜素水平与 HbA1c 升高、胰岛素抵抗、高胆固醇血症和高 LDL 胆固醇血症呈正相关。在 GDM 组中，较高的血清天冬甜素水平与 HbA1c 升高、胰岛素抵抗和低 HDL 胆固醇血症之间的显著关联仍然存在，而在非 GDM 组中，较高的血清天冬甜素水平与胰岛素抵抗和高 LDL 胆固醇血症之间存在正相关。血清三氯蔗糖水平与 HbA1c 呈负相关。
本研究发现，母体血清中天冬甜素水平与妊娠期胰岛素抵抗指数、总胆固醇和 LDL 胆固醇呈正相关。这一发现提供了特定非营养性甜味剂对妊娠期代谢健康的不同影响。
