Ethiopian Forest Development, Central Ethiopia Center, Addis Ababa, Ethiopia.
Department of Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Pharm Biol. 2023 Dec;61(1):30-36. doi: 10.1080/13880209.2022.2151021.
Plant-based natural products have served as sources of remedies against pathogenic microorganisms. Although the biological activities of (Santalaceae) species are widely recognized, there is no scientific evidence for A. Rich. in Ethiopia.
To investigate the antimicrobial, acute toxicity, anti-inflammatory properties and phytochemical constituents of an aqueous extract of from Ethiopia.
The antibacterial activity of the aqueous leaf extract of was tested against , and The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of this extract were determined using the broth macrodilution method. The acute toxicity and anti-inflammatory effects of the extract were investigated using standard procedures on female and male white albino mice, aged 8 and 10 weeks, respectively. The phytochemical constituents of were determined using LC-MS QTOF.
The MIC and MBC values against were found to be 6.25 and 100 mg/mL. The LD value was more than 2000 mg/kg body weight of the mouse. The 400 mg/kg dose exerts 87% inhibition after 5 h of carrageenan injection. Twenty-five different metabolites, mainly flavonoids, phenolic acids and alkaloids, were identified.
These findings demonstrate the potential antimicrobial and anti-inflammatory potential of the aqueous extract of .
植物源性天然产物一直是治疗致病微生物的药物来源。尽管（檀香科）物种的生物活性得到广泛认可，但在埃塞俄比亚，还没有科学证据表明 A. Rich. 具有这种作用。
研究来自埃塞俄比亚的 的抗菌、急性毒性、抗炎特性和植物化学成分。
采用肉汤微量稀释法，检测 水提物对 、 、 的抗菌活性。采用标准程序，分别在 8 周和 10 周龄雌性和雄性白化小鼠上研究提取物的急性毒性和抗炎作用。采用 LC-MS QTOF 测定 的化学成分。
发现 对 的 MIC 和 MBC 值分别为 6.25 和 100mg/mL。LD 值大于 2000mg/kg 小鼠体重。400mg/kg 剂量在角叉菜胶注射后 5 小时可发挥 87%的抑制作用。鉴定出 25 种不同的代谢物，主要为类黄酮、酚酸和生物碱。
这些发现表明 的水提物具有潜在的抗菌和抗炎作用。
