Park Jeong-Yong, Lee Ji Yeon, Kim YongGyeong, Kang Chang-Ho
MEDIOGEN, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of Korea.
Microorganisms. 2022 Dec 15;10(12):2481. doi: 10.3390/microorganisms10122481.
Ultraviolet B (UVB) exposure causes a breakdown of collagen, oxidative stress, and inflammation. UVB activates mitogen-activated protein kinase (MAPK), activator protein-1 (AP-1), and matrix metalloproteinases (MMPs). In this study, we evaluated 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity and the photoprotective effect of lactic acid bacteria LAB strains, including , , and genera in UVB-exposed skin fibroblasts. Nine LAB strains displayed antioxidant activity by regulating superoxide dismutase in UVB-exposed skin fibroblasts. Four LAB strains (MG4684, MG5368, MG4511, and MG5140) recovered type I procollagen level by inhibiting MMPs, MAPK, and AP-1 protein expression. Additionally, these four strains reduced the expression of proinflammatory cytokines by inhibiting oxidative stress. Therefore, MG4684, MG5368, MG4511, and MG5140 are potentially photoprotective.
紫外线B（UVB）照射会导致胶原蛋白分解、氧化应激和炎症。UVB会激活丝裂原活化蛋白激酶（MAPK）、活化蛋白-1（AP-1）和基质金属蛋白酶（MMPs）。在本研究中，我们评估了2,2'-联氮-双-（3-乙基苯并噻唑啉-6-磺酸）（ABTS）自由基清除活性以及包括、和属在内的乳酸菌LAB菌株在UVB照射的皮肤成纤维细胞中的光保护作用。九种LAB菌株通过调节UVB照射的皮肤成纤维细胞中的超氧化物歧化酶表现出抗氧化活性。四种LAB菌株（MG4684、MG5368、MG4511和MG5140）通过抑制MMPs、MAPK和AP-1蛋白表达恢复了I型前胶原水平。此外，这四种菌株通过抑制氧化应激降低了促炎细胞因子的表达。因此，MG4684、MG5368、MG4511和MG5140具有潜在的光保护作用。
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