Ma Jing, Gao Jingyu, Ming Cheng, Ma Xiuli, Lou Fan, Li Xia, Zhou Jun, Yang Heng, Ruan Biao, Zhang Tiesong
Department of Otorhinolaryngology Head and Neck Surgery，Kunming Children's Hospital，Kunming Key Laboratory for Prevention and Control of Congenital Birth Defects of Children，Kunming，650228，China.
Department of Otorhinolaryngology，the First Hospital of Kunming Medical University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Jan;37(1):36-41. doi: 10.13201/j.issn.2096-7993.2023.01.007.
To analyze the clinical characteristics, treatment and prognosis of the otolaryngology head and neck malignant tumors in children, in order to improve the diagnosis and treatment of the diseases. The patients of otorhinolaryngology head and neck malignant solid tumors under 14 years old hospitalized in Kunming Children's Hospital and the First Affiliated Hospital of Kunming Medical University from 2014 to 2020 were retrospectively analyzed. All cases were statistically analyzed according to gender, age, location, pathological type and treatment method. The main clinical manifestations of 91 children were mainly facial and neck masses, including nasal congestion, swallowing discomfort, and continuous intermittent fever. CT and MRI examination showed that the diameter of the tumor was 1.2 cm ×2.0 cm to 5.0 cm×12.0 cm, with a mean of 2.8 cm×3.2 cm, and 19 cases had distant metastasis. The main tissue sources were soft tissue （56 cases） and epithelial tissue （35 cases）. There were 6 pathological types, the most common was sarcoma （41 cases）, followed by neuroblastoma （15 cases）, papillary carcinoma （14 cases）, squamous cell carcinoma （10 cases）, mucoepidermoid carcinoma （8 cases）, and adenocarcinoma （3 cases）. According to the classification of tissue origin, the statistical analysis of gender and pathological type showed statistically significant differences in both gender and pathological types（<0.01）. The age of onset, primary site, tissue origin and pathological type of otolaryngology head and neck malignancy in children have their own characteristics, which should be comprehensively evaluated and treated with multidisciplinary treatment.
分析儿童耳鼻咽喉头颈恶性肿瘤的临床特征、治疗方法及预后，以提高该疾病的诊治水平。回顾性分析2014年至2020年在昆明市儿童医院及昆明医科大学第一附属医院住院治疗的14岁以下耳鼻咽喉头颈恶性实体肿瘤患儿的临床资料。所有病例均按性别、年龄、肿瘤部位、病理类型及治疗方法进行统计分析。91例患儿主要临床表现为面颈部肿块，包括鼻塞、吞咽不适及持续性间断发热。CT及MRI检查显示肿瘤直径为1.2 cm×2.0 cm至5.0 cm×12.0 cm，平均为2.8 cm×3.2 cm，19例有远处转移。主要组织来源为软组织（56例）和上皮组织（35例）。病理类型有6种，最常见的是肉瘤（41例），其次是神经母细胞瘤（15例）、乳头状癌（14例）、鳞状细胞癌（10例）、黏液表皮样癌（8例）和腺癌（3例）。按组织起源分类，对性别与病理类型进行统计分析，结果显示性别及病理类型差异均有统计学意义（<0.01）。儿童耳鼻咽喉头颈恶性肿瘤的发病年龄、原发部位、组织来源及病理类型均有其自身特点，应综合评估并采用多学科治疗。
