Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory of Material Chemistry for Energy Conversion and Storage (Ministry of Education), Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Rd, 430074, Wuhan, PR China.
Secretariat license de chimie, bâtiment 460, Université Paris-saclay, 91400, Orsay, Paris, France.
Nat Commun. 2023 Jan 5;14(1):69. doi: 10.1038/s41467-022-35721-4.
Sweat sensors play a significant role in personalized healthcare by dynamically monitoring biochemical markers to detect individual physiological status. The specific response to the target biomolecules usually depends on natural oxidase, but it is susceptible to external interference. In this work, we report tryptophan- and histidine-treated copper metal-organic frameworks (Cu-MOFs). This amino-functionalized copper-organic framework shows highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors. Experiments and calculation results elucidate that the introduced tryptophan/histidine fundamentally regulates the adsorption behaviors of biomolecules, enabling ascorbate to be selectively captured from complex sweat and further efficiently electrooxidized. This work provides not only a paradigm for specifically sweat sensing but also a significant understanding of natural oxidase-inspired MOF nanoenzymes for sensing technologies and beyond.
汗液传感器通过动态监测生物化学标志物来检测个体生理状态，在个性化医疗保健中发挥着重要作用。对目标生物分子的特定响应通常取决于天然氧化酶，但它易受外部干扰。在这项工作中，我们报告了色氨酸和组氨酸处理的铜金属有机骨架（Cu-MOFs）。这种氨基酸功能化的铜有机骨架对抗坏血酸氧化具有高度选择性活性，可作为敏感汗液传感器中的高效抗坏血酸氧化酶模拟材料。实验和计算结果阐明，引入的色氨酸/组氨酸从根本上调节了生物分子的吸附行为，使抗坏血酸能够从复杂的汗液中选择性捕获，并进一步有效地电氧化。这项工作不仅为特异性汗液传感提供了范例，而且为受自然氧化酶启发的 MOF 纳米酶在传感技术等领域的应用提供了深入的理解。
