Department of Stomatology and Maxillofacial Surgery, Faculty of Medicine, Comenius University in Bratislava, Heydukova 10, 812 50 Bratislava, Slovakia.
Department of Stomatology and Maxillofacial Surgery, St. Elizabeth's Hospital, Heydukova 10, 812 50 Bratislava, Slovakia.
Molecules. 2022 Dec 24;28(1):158. doi: 10.3390/molecules28010158.
Medicinal plants are rich sources of valuable molecules with various profitable biological effects, including antimicrobial activity. The advantages of herbal products are their effectiveness, relative safety based on research or extended traditional use, and accessibility without prescription. Extensive and irrational usage of antibiotics since their discovery in 1928 has led to the increasing expiration of their effectiveness due to antibacterial resistance. Now, medical research is facing a big and challenging mission to find effective and safe antimicrobial therapies to replace inactive drugs. Over the years, one of the research fields that remained the most available is the area of natural products: medicinal plants and their metabolites, which could serve as active substances to fight against microbes or be considered as models in drug design. This review presents selected flavonoids (such as apigenin, quercetin, kaempferol, kurarinone, and morin) and tannins (including oligomeric proanthocyanidins, gallotannins, ellagitannins, catechins, and epigallocatechin gallate), but also medicinal plants rich in these compounds as potential therapeutic agents in oral infectious diseases based on traditional usages such as L., L., L., L., L., L., L., or (L.). Some of the presented compounds and extracts are already successfully used to maintain oral health, as the main or additive ingredient of toothpastes or mouthwashes. Others are promising for further research or future applications.
药用植物是具有各种有益生物活性的有价值分子的丰富来源，包括抗菌活性。草药产品的优点是它们的有效性、基于研究或广泛传统使用的相对安全性，以及无需处方即可获得。自 1928 年发现抗生素以来，抗生素的广泛和不合理使用导致其有效性因抗菌耐药性而逐渐失效。现在，医学研究面临着一个艰巨而具有挑战性的任务，即为替代无效药物寻找有效和安全的抗菌治疗方法。多年来，最可行的研究领域之一是天然产物领域：药用植物及其代谢物，它们可以作为对抗微生物的活性物质，或者可以作为药物设计的模型。这篇综述介绍了一些黄酮类化合物（如芹菜素、槲皮素、山奈酚、苦参酮和桑色素）和单宁（包括低聚原花青素、没食子单宁、鞣花单宁、儿茶素和没食子酸表没食子儿茶素酯），以及富含这些化合物的药用植物，基于传统用途，如 L.、 L.、 L.、 L.、 L.、 L.、 L. 或 （L.），它们可作为口腔传染病的潜在治疗剂。本文介绍的一些化合物和提取物已经成功地用于维持口腔健康，作为牙膏或漱口水的主要或添加剂成分。其他一些则具有进一步研究或未来应用的潜力。
