肌醇磷酸的结合以及垂体微粒体组分中钙离子的释放诱导
Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions.
作者信息
Spät A, Lukács G L, Eberhardt I, Kiesel L, Runnebaum B
机构信息
Department of Physilogy, Semmelweis University Medical School, Budapest, Hungary.
出版信息
Biochem J. 1987 Jun 1;244(2):493-6. doi: 10.1042/bj2440493.
Abstract
Bovine anterior-pituitary microsomal fractions exhibit high-affinity, saturable and reversible binding of inositol 1,4,5-[32P]trisphosphate; 50% of the labelled ligand is displaced by 3.5 nM-inositol 1,4,5-trisphosphate. 0.5 microM-inositol 1,4-bisphosphate and 10 microM-ATP. Inositol 1,4,5-trisphosphate induces the release of Ca2+ from the microsomal vesicles (half-maximal effect at 290 nM), and its action is potentiated by inositol tetrakisphosphate (half-maximal effect at 4 microM).
摘要
牛垂体前叶微粒体部分表现出对肌醇1,4,5-[32P]三磷酸的高亲和力、可饱和且可逆的结合；3.5 nM肌醇1,4,5-三磷酸可置换50%的标记配体。0.5 microM肌醇1,4-二磷酸和10 microM三磷酸腺苷也有此作用。肌醇1,4,5-三磷酸可诱导微粒体囊泡释放Ca2+（290 nM时达到最大效应的一半），其作用可被肌醇四磷酸增强（4 microM时达到最大效应的一半）。
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本文引用的文献
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Inositol (1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver.肌醇（1,4,5）三磷酸促进大鼠肝脏微粒体组分释放钙离子。
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Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.促甲状腺激素释放激素能迅速激活GH3垂体细胞中多磷酸肌醇的磷酸二酯水解。多磷酸肌醇特异性磷脂酶C在激素作用中的作用证据。
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Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.肌醇三磷酸的快速积累表明，激动剂水解多磷酸肌醇而非磷脂酰肌醇。
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