College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin 150081, China.
Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Road, Harbin 150081, China.
Database (Oxford). 2023 Jan 19;2023. doi: 10.1093/database/baac113.
ENCD (http://www.bio-server.cn/ENCD/) is a manually curated database that provides comprehensive experimentally supported associations among endocrine system diseases (ESDs) and long non-coding ribonucleic acid (lncRNAs). The incidence of ESDs has increased in recent years, often accompanying other chronic diseases, and can lead to disability. A growing body of research suggests that lncRNA plays an important role in the progression and metastasis of ESDs. However, there are no resources focused on collecting and integrating the latest and experimentally supported lncRNA-ESD associations. Hence, we developed an ENCD database that consists of 1379 associations between 35 ESDs and 501 lncRNAs in 12 human tissues curated from literature. By using ENCD, users can explore the genetic data for diseases corresponding to the body parts of interest as well as study the lncRNA regulating mechanism for ESDs. ENCD also provides a flexible tool to visualize a disease- or gene-centric regulatory network. In addition, ENCD offers a submission page for researchers to submit their newly discovered endocrine disorders-genetic data entries online. Collectively, ENCD will provide comprehensive insights for investigating the ESDs associated with lncRNAs. Database URL http://www.bio-server.cn/ENCD.
ENCD（http://www.bio-server.cn/ENCD/）是一个手动整理的数据库，提供了内分泌系统疾病（ESD）和长非编码核糖核酸（lncRNA）之间经过充分实验验证的关联的全面信息。近年来，ESD 的发病率有所增加，常伴有其他慢性疾病，并可能导致残疾。越来越多的研究表明，lncRNA 在 ESD 的进展和转移中起着重要作用。然而，目前还没有专门用于收集和整合最新的经过实验验证的 lncRNA-ESD 关联的资源。因此，我们开发了一个 ENCD 数据库，其中包含 1379 种来自文献的关联，涉及 35 种 ESD 和 12 个人体组织中的 501 个 lncRNA。通过使用 ENCD，用户可以探索与感兴趣身体部位相对应的疾病的遗传数据，并研究 ESD 的 lncRNA 调节机制。ENCD 还提供了一个灵活的工具，用于可视化疾病或基因为中心的调节网络。此外，ENCD 还为研究人员提供了一个提交页面，用于在线提交他们新发现的内分泌失调-遗传数据条目。总的来说，ENCD 将为研究与 lncRNA 相关的 ESD 提供全面的见解。数据库网址：http://www.bio-server.cn/ENCD。
