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当前单细胞外囊泡分析技术的进展及其在癌症诊断中的临床应用。

Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis.

机构信息

Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China.

Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.

出版信息

Biosensors (Basel). 2023 Jan 12;13(1):129. doi: 10.3390/bios13010129.

DOI:10.3390/bios13010129
PMID:36671964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9856491/
Abstract

Extracellular vesicles (EVs) have been regarded as one of the most potential diagnostic biomarkers for different cancers, due to their unique physiological and pathological functions. However, it is still challenging to precisely analyze the contents and sources of EVs, due to their heterogeneity. Herein, we summarize the advances in technologies for a single EV analysis, which may provide new strategies to study the heterogeneity of EVs, as well as their cargo, more specifically. Furthermore, the applications of a single EV analysis on cancer early diagnosis are also discussed.

摘要

细胞外囊泡 (EVs) 因其独特的生理和病理功能而被认为是不同癌症最有潜力的诊断生物标志物之一。然而，由于其异质性，精确分析 EV 的内容物和来源仍然具有挑战性。本文总结了用于单个 EV 分析的技术进展，这可能为研究 EV 及其 cargo 的异质性提供新的策略。此外，还讨论了单个 EV 分析在癌症早期诊断中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/883789753493/biosensors-13-00129-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/b8fb13955d5e/biosensors-13-00129-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/e4b11de1af0b/biosensors-13-00129-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/117ac7d3fc08/biosensors-13-00129-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/9b8269ab24b2/biosensors-13-00129-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/6ff95f03e777/biosensors-13-00129-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/58893263bca9/biosensors-13-00129-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/bd84b6c9c65d/biosensors-13-00129-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/a13c9f15b7df/biosensors-13-00129-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/633537f20987/biosensors-13-00129-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/bc7f6cb61985/biosensors-13-00129-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/bd2f47023632/biosensors-13-00129-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/3ba900c47e82/biosensors-13-00129-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/883789753493/biosensors-13-00129-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/b8fb13955d5e/biosensors-13-00129-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/e4b11de1af0b/biosensors-13-00129-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/117ac7d3fc08/biosensors-13-00129-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/9b8269ab24b2/biosensors-13-00129-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/6ff95f03e777/biosensors-13-00129-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/58893263bca9/biosensors-13-00129-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/bd84b6c9c65d/biosensors-13-00129-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/a13c9f15b7df/biosensors-13-00129-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/633537f20987/biosensors-13-00129-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/bc7f6cb61985/biosensors-13-00129-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/bd2f47023632/biosensors-13-00129-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/3ba900c47e82/biosensors-13-00129-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/9856491/883789753493/biosensors-13-00129-g013.jpg

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