Al Fatease Adel, Abourehab Mohammed A S, Alqahtani Ali M, Chidambaram Kumarappan, Qureshi Absar Ahmed, Venkatesan Krishnaraju, Alshahrani Sultan M, Abdelkader Hamdy
Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Pharmaceuticals (Basel). 2022 Dec 27;16(1):38. doi: 10.3390/ph16010038.
Curcumin is the main active constituent in turmeric, and it is one of the biopolyphenolic compounds. A cumulative body of research supports the use of curcumin in the treatment of wounds, yet poor water solubility and lack of therapeutic dose determination hamper its use for this therapeutic purpose. This work aimed at preparing novel curcumin wafer dressings to provide a favorable environment for wound healing. Hybrid synthetic (PVA, PVP, HPMC, and CMC) and biodegradable (sodium alginate and dextran) polymers were employed to prepare wafer dressings loaded with incremental three doses (2, 10, and 20 mg) of curcumin per a wafer dressing. The solvent casting method was used to prepare the dressings. Dimension, surface pH, mechanical properties, DSC, FTIR, XRD, erosion time, and in vitro release were studied. Skin wound healing assay was studied in Wistar albino rats. Six curcumin-loaded wafers were successfully prepared with good mechanical properties. Curcumin was dispersed in an amorphous/molecular form, as evidenced by thermal (DSC) and spectral (FTIR and XRD) analyses. Prolonged curcumin release (>24 h) was recorded for F6 (10 mg curcumin) and F7 (20 mg curcumin). Wound healing rate constants and time for 50% wound closure (T1/2) were estimated from a semi-log wound diameter versus time curve. A superior healing rate (up to 3-fold faster) was recorded for curcumin-loaded wafer dressings containing 10 mg (F6) with T1/2 of 7 days compared to 20 days for the placebo-treated group. These results warrant using the selected curcumin-loaded wafer dressing for safer and faster wound closure.
姜黄素是姜黄中的主要活性成分，也是生物多酚类化合物之一。大量研究支持姜黄素用于伤口治疗，但其水溶性差且缺乏治疗剂量的确定，阻碍了其在此治疗目的中的应用。这项工作旨在制备新型姜黄素薄片敷料，为伤口愈合提供有利环境。采用混合合成聚合物（聚乙烯醇、聚乙烯吡咯烷酮、羟丙基甲基纤维素和羧甲基纤维素）和可生物降解聚合物（海藻酸钠和葡聚糖）制备每片敷料含有递增三剂量（2、10和20毫克）姜黄素的薄片敷料。采用溶剂浇铸法制备敷料。研究了其尺寸、表面pH值、机械性能、差示扫描量热法（DSC）、傅里叶变换红外光谱法（FTIR）、X射线衍射法（XRD）、侵蚀时间和体外释放情况。在Wistar白化大鼠中进行了皮肤伤口愈合试验。成功制备了六种具有良好机械性能的载姜黄素薄片。热分析（DSC）和光谱分析（FTIR和XRD）表明，姜黄素以无定形/分子形式分散。F6（10毫克姜黄素）和F7（20毫克姜黄素）记录到姜黄素的延长释放（>24小时）。根据半对数伤口直径与时间曲线估算伤口愈合速率常数和50%伤口闭合时间（T1/2）。与安慰剂治疗组的20天相比，含10毫克姜黄素的载姜黄素薄片敷料（F6）的愈合速率更高（快达3倍），T1/2为7天。这些结果证明使用所选的载姜黄素薄片敷料可实现更安全、更快的伤口闭合。
