Das Upama, Banik Soumyabrata, Nadumane Sharmila Sajankila, Chakrabarti Shweta, Gopal Dharshini, Kabekkodu Shama Prasada, Srisungsitthisunti Pornsak, Mazumder Nirmal, Biswas Rajib
Applied Optics and Photonics Laboratory, Department of Physics, Tezpur University, Tezpur 784028, Assam, India.
Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Pharmaceutics. 2023 Jan 13;15(1):280. doi: 10.3390/pharmaceutics15010280.
Cancer is one of the dreaded diseases to which a sizeable proportion of the population succumbs every year. Despite the tremendous growth of the health sector, spanning diagnostics to treatment, early diagnosis is still in its infancy. In this regard, circulating tumour cells (CTCs) have of late grabbed the attention of researchers in the detection of metastasis and there has been a huge surge in the surrounding research activities. Acting as a biomarker, CTCs prove beneficial in a variety of aspects. Nanomaterial-based strategies have been devised to have a tremendous impact on the early and rapid examination of tumor cells. This review provides a panoramic overview of the different nanotechnological methodologies employed along with the pharmaceutical purview of cancer. Initiating from fundamentals, the recent nanotechnological developments toward the detection, isolation, and analysis of CTCs are comprehensively delineated. The review also includes state-of-the-art implementations of nanotechnological advances in the enumeration of CTCs, along with future challenges and recommendations thereof.
癌症是一种可怕的疾病，每年都有相当一部分人死于这种疾病。尽管医疗行业从诊断到治疗都有了巨大发展，但早期诊断仍处于起步阶段。在这方面，循环肿瘤细胞（CTC）最近在转移检测中引起了研究人员的关注，相关研究活动也大幅增加。作为一种生物标志物，CTC在多个方面都被证明是有益的。基于纳米材料的策略已被设计出来，对肿瘤细胞的早期快速检测产生巨大影响。本综述全面概述了所采用的不同纳米技术方法以及癌症的药学范畴。从基础开始，全面阐述了最近在CTC检测、分离和分析方面的纳米技术发展。该综述还包括纳米技术进展在CTC计数方面的最新应用，以及未来的挑战和相关建议。
