高水平的[具体物质未给出]与帕金森病的发病机制有关。
High levels of are associated with the pathogenesis of Parkinson's disease.
作者信息
Zuo ShuJia, Wang HaiJing, Zhao Qiang, Tang Jie, Wang Min, Zhang Yu, Sang Ming, Tian Jing, Wang Puqing
机构信息
Postgraduate Union Training Base of Jinzhou Medical University, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China.
Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China.
出版信息
Front Integr Neurosci. 2023 Jan 4;16:1054627. doi: 10.3389/fnint.2022.1054627. eCollection 2022.
BACKGROUND
The diagnosis of Parkinson's disease (PD) is complex and there are no biomarkers for early identification. Many studies have reported altered gut microbiota in patients with PD compared with healthy individuals. However, results from previous studies vary across countries.
AIMS
The aim of this study was to identify gut microbiota biomarkers that could be used as a marker for the diagnosis of PD.
METHODS
Firstly, the differential gut microbiota was obtained by meta-analysis, and then the results of meta-analysis were validated through metagenomic cohort. Finally, the ROC curve was drawn based on the metagenomic validation results.
RESULTS
The meta-analysis showed a lower relative abundance of ( < 0.00001) and ( = 0.002), and a higher of ( < 0.00001), ( = 0.03), ( < 0.00001), and ( = 0.02) in patients with PD. Only was also at high levels in the validation cohort of the metagenome. Meanwhile, three species from the , including ( = 0.022), ( = 0.005), and ( = 0.024) were also high. The ROC curve showed that the three species (71.2%) from had good predictive efficiency for PD.
CONCLUSION
Elevated may be associated with PD. Elevated three species from the , including , and may provide new potential biomarkers for the diagnosis of PD.
背景
帕金森病（PD）的诊断复杂，且尚无用于早期识别的生物标志物。许多研究报告称，与健康个体相比，PD患者的肠道微生物群发生了改变。然而，以往研究的结果在不同国家有所不同。
目的
本研究旨在确定可作为PD诊断标志物的肠道微生物群生物标志物。
方法
首先，通过荟萃分析获得差异肠道微生物群，然后通过宏基因组队列验证荟萃分析结果。最后，根据宏基因组验证结果绘制ROC曲线。
结果
荟萃分析显示，PD患者中 （<0.00001）和 （=0.002）的相对丰度较低，而 （<0.00001）、 （=0.03）、 （<0.00001）和 （=0.02）的相对丰度较高。在宏基因组验证队列中，只有 在高水平时也存在。同时，来自 的三个物种，包括 （=0.022）、 （=0.005）和 （=0.024）也处于高水平。ROC曲线显示，来自 的三个物种（71.2%）对PD具有良好的预测效率。
结论
的升高可能与PD有关。来自 的三个物种，包括 、 和 的升高可能为PD的诊断提供新的潜在生物标志物。
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