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中国西南地区成年人维生素 D 状况的种族、地理和季节差异。

Ethnic, geographic, and seasonal differences of vitamin D status among adults in south-west China.

机构信息

Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

出版信息

J Clin Lab Anal. 2020 Dec;34(12):e23532. doi: 10.1002/jcla.23532. Epub 2020 Aug 26.

DOI:10.1002/jcla.23532
PMID:32851701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7755805/
Abstract

BACKGROUND

There are limited data on vitamin D status of Sichuan province, and no investigation has been carried out on the correlations of 25(OH)D and BTMs between healthy Hans and Tibetans of Sichuan province. This study aimed to examine 25(OH)D levels around Sichuan province and to assess differences by ethnicity, age, gender, sunlight exposure, geographic location, and seasons.

METHODS

Blood samples from 2317 healthy adults aged of 18 to 75 years and of Han and Tibetan ethnicities were collected in six regions and during four seasons. Serum 25(OH)D and 25(OH)D levels were measured by LC-MS/MS method. Serum total P1NP and β-CTX were measured by immunoassay.

RESULTS

Participants aged 18-40 years showed significantly lower 25(OH)D levels than participants aged 41-75 years old (P < .0001). The median serum 25(OH)D level for males was significantly higher than that of females (P < .0001). Serum 25(OH)D levels among four seasons and different districts varied significantly (P < .0001). In addition, the 25(OH)D level of Tibetans was significantly lower than that of Hans, while the serum total P1NP and β-CTX levels of Tibetans were significantly higher than those of Hans (P < .0001).

CONCLUSION

Adult population was more common to have vitamin D deficiency/insufficiency among Tibetans, females, north regions and in spring and winter.

摘要

背景

四川省的维生素 D 状况数据有限，尚未对四川省健康汉族人和藏族人 25(OH)D 和 BTMs 之间的相关性进行调查。本研究旨在检查四川省周围的 25(OH)D 水平，并评估种族、年龄、性别、阳光照射、地理位置和季节的差异。

方法

从六个地区和四个季节采集了 2317 名年龄在 18 至 75 岁之间的健康汉族和藏族成年人的血液样本。使用 LC-MS/MS 方法测量血清 25(OH)D 和 25(OH)D 水平。使用免疫测定法测量血清总 P1NP 和 β-CTX。

结果

18-40 岁的参与者的 25(OH)D 水平明显低于 41-75 岁的参与者（P<.0001）。男性的血清 25(OH)D 中位数明显高于女性（P<.0001）。四个季节和不同地区的血清 25(OH)D 水平差异显著（P<.0001）。此外，藏族人的 25(OH)D 水平明显低于汉族人，而藏族人的血清总 P1NP 和 β-CTX 水平明显高于汉族人（P<.0001）。

结论

在藏族人、女性、北部地区以及春季和冬季，成年人中维生素 D 缺乏/不足更为常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/03bb57df0466/JCLA-34-e23532-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/ab6a0b5acbc8/JCLA-34-e23532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/4ef615cd88d4/JCLA-34-e23532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/f2d415623591/JCLA-34-e23532-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/b231c9c93d8f/JCLA-34-e23532-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/7c57aa8a57d7/JCLA-34-e23532-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/03bb57df0466/JCLA-34-e23532-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/ab6a0b5acbc8/JCLA-34-e23532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/4ef615cd88d4/JCLA-34-e23532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/f2d415623591/JCLA-34-e23532-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/b231c9c93d8f/JCLA-34-e23532-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/7c57aa8a57d7/JCLA-34-e23532-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/7755805/03bb57df0466/JCLA-34-e23532-g006.jpg

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