School of Public Health, Medical College of Soochow University, Suzhou, China.
Department of Ophthalmology, The First Affiliated Hospital of Dali University, Dali, China.
Eye (Lond). 2023 Sep;37(13):2723-2729. doi: 10.1038/s41433-023-02405-2. Epub 2023 Jan 25.
BACKGROUND/OBJECTIVES: Smoking and alcohol consumption are important risk factors for several ocular disorders, but their effects on corneal biomechanics remain unclear. Our study aims to explore the association between smoking and alcohol consumption with corneal biomechanical parameters measured by Corvis-ST (CST) among university students.
SUBJECTS/METHODS: A total of 1645 healthy university students from a university-based study were included, and all participants underwent corneal biomechanical parameters measurement by CST. We selected 10 reliable parameters that can reflect the corneal deformation response. All participants had a standardised interview to determine their smoking and alcohol consumption status.
The mean age of the participants was 19.0 ± 0.9 years, and 1132 (68.8%) were women. Smoking was significantly associated with stiffer corneas. Smokers showed significantly slower second applanation velocity (A2v) (β = 0.007 m/s, 95% confidence interval 0.001 to 0.014, P = 0.032) and lower integrated radius (IR) (β = -0.214 mm, 95% confidence interval -0.420 to -0.007, P = 0.043) than non-smokers after adjusting for age, gender, eye-rubbing, myopia, and body mass index (BMI). Smokers with BMI no less than 24.0 showed slower A2v and lower IR. Alcohol consumption and passive smoking were found no significant association with corneal biomechanics.
Smokers had less deformable corneas, especially those with BMI no less than 24.0. Our findings provide new evidence for the association between smoking and ocular disorders associated with corneal biomechanics like glaucoma.
背景/目的：吸烟和饮酒是几种眼部疾病的重要危险因素，但它们对角膜生物力学的影响尚不清楚。我们的研究旨在探讨大学生中吸烟和饮酒与 Corvis-ST（CST）测量的角膜生物力学参数之间的关系。
受试者/方法：一项基于大学的研究共纳入了 1645 名健康大学生，所有参与者均接受 CST 测量角膜生物力学参数。我们选择了 10 个可靠的参数来反映角膜变形反应。所有参与者都接受了标准访谈，以确定他们的吸烟和饮酒状况。
参与者的平均年龄为 19.0±0.9 岁，其中 1132 名（68.8%）为女性。吸烟与角膜硬度增加显著相关。吸烟者的第二次压平速度（A2v）明显较慢（β=0.007m/s，95%置信区间 0.001 至 0.014，P=0.032），整合半径（IR）较低（β=-0.214mm，95%置信区间-0.420 至-0.007，P=0.043），调整年龄、性别、揉眼、近视和体重指数（BMI）后。BMI 不低于 24.0 的吸烟者 A2v 更慢，IR 更低。饮酒和被动吸烟与角膜生物力学无显著相关性。
吸烟者的角膜变形能力较低，尤其是 BMI 不低于 24.0 的吸烟者。我们的研究结果为吸烟与与角膜生物力学相关的眼部疾病（如青光眼）之间的关系提供了新的证据。
