Department of Dermatology, Institute of Dermatology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
College of Life Science and Oceanography, Shenzhen University, Shenzhen, China.
Front Cell Infect Microbiol. 2023 Jan 10;12:1105811. doi: 10.3389/fcimb.2022.1105811. eCollection 2022.
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. The gastric microbiota plays a critical role in the development of GC. First, () infection is considered a major risk factor for GC. However, recent studies based on microbiota sequencing technology have found that non- microbes also exert effects on gastric carcinogenesis. Following the infection of , gastric microbiota dysbiosis could be observed; the stomach is dominated by and the abundances of non- microbes reduce substantially. Additionally, decreased microbial diversity, alterations in the microbial community structure, negative interactions between and other microbes, etc. occur, as well. With the progression of gastric lesions, the number of decreases and the number of non- microbes increases correspondingly. Notably, and non- microbes show different roles in different stages of gastric carcinogenesis. In the present mini-review, we provide an overview of the recent findings regarding the role of the gastric microbiota, including the and non- microbes, in the development of GC.
胃癌（GC）是全球癌症相关死亡的主要原因之一。胃微生物群在 GC 的发展中起着关键作用。首先，()感染被认为是 GC 的主要危险因素。然而，基于微生物测序技术的最近研究发现，非微生物也对胃致癌作用产生影响。在感染()后，可观察到胃微生物失调；胃主要被()占据，非微生物的丰度大大降低。此外，还会发生微生物多样性减少、微生物群落结构改变、()与其他微生物之间的负相互作用等。随着胃病变的进展，()的数量减少，相应地，非()的数量增加。值得注意的是，()和非()在胃癌变的不同阶段发挥不同的作用。在本综述中，我们概述了胃微生物群（包括()和非()）在 GC 发展中的作用的最新发现。
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