Wei Qian, Liu Xi, Su Jian-Long, Wang Ya-Xi, Chu Zi-Qiang, Ma Kui, Huang Qi-Lin, Li Hai-Hong, Fu Xiao-Bing, Zhang Cui-Ping
Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and the 4th Medical Center of Chinese, PLA General Hospital, Beijing, China.
Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Research Unit of Trauma Care, Beijing, China.
Front Bioeng Biotechnol. 2023 Jan 10;10:1083459. doi: 10.3389/fbioe.2022.1083459. eCollection 2022.
Chronic non-healing wounds have posed a severe threat to patients mentally and physically. Behavior dysregulation of remaining cells at wound sites is recognized as the chief culprit to destroy healing process and hinders wound healing. Therefore, regulating and restoring normal cellular behavior is the core of chronic non-healing wound treatment. In recent years, the therapy with mesenchymal stem cells (MSCs) has become a promising option for chronic wound healing and the efficacy has increasingly been attributed to their exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs) are reported to benefit almost all stages of wound healing by regulating the cellular behavior to participate in the process of inflammatory response, angiogenesis, re-epithelization, and scarless healing. Here, we describe the characteristics of MSC-sEVs and discuss their therapeutic potential in chronic wound treatment. Additionally, we also provide an overview of the application avenues of MSC-sEVs in wound treatment. Finally, we summarize strategies for large-scale production and engineering of MSC-sEVs. This review may possibly provide meaningful guidance for chronic wound treatment with MSC-sEVs.
慢性难愈合伤口对患者的身心健康构成了严重威胁。伤口部位残留细胞的行为失调被认为是破坏愈合过程并阻碍伤口愈合的主要原因。因此，调节和恢复正常细胞行为是慢性难愈合伤口治疗的核心。近年来，间充质干细胞（MSC）治疗已成为慢性伤口愈合的一种有前景的选择，其疗效越来越多地归因于它们的外分泌功能。据报道，源自MSC的小细胞外囊泡（MSC-sEV）通过调节细胞行为参与炎症反应、血管生成、再上皮化和无瘢痕愈合过程，几乎对伤口愈合的所有阶段都有益。在此，我们描述了MSC-sEV的特征，并讨论了它们在慢性伤口治疗中的治疗潜力。此外，我们还概述了MSC-sEV在伤口治疗中的应用途径。最后，我们总结了MSC-sEV大规模生产和工程化的策略。这篇综述可能为使用MSC-sEV治疗慢性伤口提供有意义的指导。
