Diversity and Antimicrobial Activities of Isolated from Mining Soils in Midelt Region, Morocco.

Multidrug-resistant bacteria have emerged as a serious global health threat that requires, more than ever before, an urgent need for novel and more effective drugs. In this regard, the present study sheds light on the diversity and antimicrobial potential of isolates in mining ecosystems. We have indeed investigated the production of bioactive molecules by the isolated from abandoned mining areas in Midelt, Morocco, where average contents of lead (Pb) and cadmium (Cd) are higher than normal world levels. One hundred and forty-five isolates were isolated and characterized based on morphological, chemotaxonomical, biochemical, and molecular data. Most of the 145 isolates were identified as . Isolates affiliated to the genera , , , and were also found. Antimicrobial producing potentials of isolates were assessed against eight test microorganisms Gram and Gram bacteria and yeast. Out of 145 isolates, 51 showed antimicrobial activities against at least one test microorganism. 31 isolates inhibited only bacteria, 7 showed activity against bacteria and , and 13 displayed activity against . solely. Our findings suggest that isolated from natural heavy metal ecosystems may be a valuable source of novel secondary metabolites and therefore of new biotechnologically promising antimicrobial compounds.