General Surgery, Huadong Hospital Affiliated to Fudan University, 221 Yan 'an West Road, Jing 'an District, Shanghai, Shanghai, 200040, China.
Rapid Manufacturing Engineering Center, Shanghai University, 99 Shangda Road, Baoshan District, Shanghai, Shanghai, 200444, China.
Macromol Biosci. 2023 Apr;23(4):e2200521. doi: 10.1002/mabi.202200521. Epub 2023 Feb 12.
Abdominal wall defects are a frequently occurring condition in surgical practice. The most important are material structure and biocompatibility. In this study, polylactic acid (PLA) mesh composited with a 3D printing of acellular dermal matrix (ADM) material is used to repair abdominal wall defects. The results show that the adhesion score of ADM/PLA composite scaffolds is smaller than PLA meshes. Immunohistochemical assessment reveals that the ADM/PLA composite scaffold can effectively reduce the inflammatory response at the contact surface between the meshes and the abdominal organs. And the ADM/PLA composite scaffold can effectively reduce the expression levels of the inflammation-related factors IL-6 and IL-10. In addition, the ADM/PLA composite scaffold repair is rich in the expression levels of tissue regeneration-related factors vascular endothelial growth factor and transforming growth factor β. Thus, ADM/PLA composite scaffolds can effectively reduce surrounding inflammation to effectively promote the repair of abdominal wall defects.
腹壁缺陷是外科实践中经常发生的一种情况。最重要的是材料结构和生物相容性。在这项研究中，使用聚乳酸（PLA）网复合脱细胞真皮基质（ADM）材料来修复腹壁缺陷。结果表明，ADM/PLA 复合支架的粘附评分小于 PLA 网。免疫组织化学评估显示，ADM/PLA 复合支架可有效降低网片与腹腔脏器接触表面的炎症反应。ADM/PLA 复合支架可有效降低炎症相关因子 IL-6 和 IL-10 的表达水平。此外，ADM/PLA 复合支架修复富含组织再生相关因子血管内皮生长因子和转化生长因子β的表达水平。因此，ADM/PLA 复合支架可以有效减轻周围炎症，有效促进腹壁缺陷的修复。
