Mazzulli Tony, Ratkov Dimitrije, Guglielmin Kristyn, Gandhi Bharat, Remington Richard, Birch Robert, Zimmer Louise, Garner Cherilyn D
Department of Microbiology, University Health Network/Mount Sinai Hospital, Toronto, Ontario, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Microbiol Spectr. 2023 Feb 7;11(2):e0500322. doi: 10.1128/spectrum.05003-22.
Time to positivity (TTP) for blood culture bottles incubated in the BacT/Alert Virtuo instrument was compared to the BacT/Alert 3D. TTP was significantly shorter with the Virtuo (median 16.2 h) than 3D (median 21.1 h; 0.001). Switching from 3D to Virtuo significantly improved TTP in this multicenter hospital setting study. Sepsis affects millions of people around the world each year, and accounts for a significant number of deaths in hospital intensive care units (ICU). Timely diagnosis is key to decreasing morbidity and mortality. One important element of sepsis diagnosis is organism detection using blood cultures. In this study, we examined the impact of implementing the BacT/Alert Virtuo automated blood culture detection system on time to positivity in an ICU patient population at a multicenter hospital setting.
将在BacT/Alert Virtuo仪器中孵育的血培养瓶的阳性时间（TTP）与BacT/Alert 3D进行了比较。Virtuo的TTP（中位数16.2小时）明显短于3D（中位数21.1小时；P = 0.001）。在这项多中心医院环境研究中，从3D切换到Virtuo显著改善了TTP。脓毒症每年影响全球数百万人，并在医院重症监护病房（ICU）导致大量死亡。及时诊断是降低发病率和死亡率的关键。脓毒症诊断的一个重要要素是使用血培养进行病原体检测。在本研究中，我们在多中心医院环境下，研究了实施BacT/Alert Virtuo自动血培养检测系统对ICU患者群体阳性时间的影响。
