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非编码 RNA 在肝脏疾病、损伤和再生中的作用。

The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration.

机构信息

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, PA 19014, USA.

出版信息

Cells. 2023 Jan 18;12(3):359. doi: 10.3390/cells12030359.

Abstract

Non-coding RNAs (ncRNAs) have diverse functions in health and pathology in many tissues, including the liver. This review highlights important microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in liver disease and regeneration. Greater attention is given to more prevalent and well characterized RNAs, including: miR-122, miR-21, the let-7 family of miRs, miR-451a, miR-144, and MALAT1.

摘要

非编码 RNA(ncRNAs)在包括肝脏在内的许多组织的健康和病理中具有多种功能。本综述重点介绍了肝脏疾病和再生中重要的 microRNAs(miRs)、长非编码 RNA(lncRNAs)和 circular RNAs(circRNAs)。更多关注更普遍和特征更明显的 RNA,包括:miR-122、miR-21、miR-let-7 家族、miR-451a、miR-144 和 MALAT1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e958/9914052/1be588924b13/cells-12-00359-g001.jpg

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