Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, PA 19014, USA.
Cells. 2023 Jan 18;12(3):359. doi: 10.3390/cells12030359.
Non-coding RNAs (ncRNAs) have diverse functions in health and pathology in many tissues, including the liver. This review highlights important microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in liver disease and regeneration. Greater attention is given to more prevalent and well characterized RNAs, including: miR-122, miR-21, the let-7 family of miRs, miR-451a, miR-144, and MALAT1.
非编码 RNA(ncRNAs)在包括肝脏在内的许多组织的健康和病理中具有多种功能。本综述重点介绍了肝脏疾病和再生中重要的 microRNAs(miRs)、长非编码 RNA(lncRNAs)和 circular RNAs(circRNAs)。更多关注更普遍和特征更明显的 RNA,包括:miR-122、miR-21、miR-let-7 家族、miR-451a、miR-144 和 MALAT1。