3D 打印 pH 指示剂各向异性水凝胶皮肤创伤敷料。

3D Printing of pH Indicator Auxetic Hydrogel Skin Wound Dressing.

机构信息

Department of Mechanical Engineering, Khalifa University, Abu Dhabi 127788, United Arab Emirates.

出版信息

Molecules. 2023 Jan 31;28(3):1339. doi: 10.3390/molecules28031339.

DOI:10.3390/molecules28031339

PMID:36771005

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9920873/

Abstract

The benefits of enclosing pH sensors into wound dressings include treatment monitoring of wounded skin and early detection of developing chronic conditions, especially for diabetic patients. A 3D printed re-entrant auxetic hydrogel wound dressing, doped with pH indicator phenol red dye, was developed and characterized. The re-entrant auxetic design allows wound dressing adhesion to complex body parts, such as joints on arms and legs. Tensile tests revealed a yield strength of 140 kPa and Young's modulus of 78 MPa. In addition, the 3D-printed hydrogel has a swelling capacity of up to 14%, limited weight loss to 3% in six days, and porosity of near 1.2%. A reasonable pH response resembling human skin pH (4-10) was obtained and characterized. The integration of color-changing pH indicators allows patients to monitor the wound's healing process using a smartphone. In addition to the above, the mechanical properties and their dependence on post-processing were studied. The results show that the resin composition and the use of post-treatments significantly affect the quality and durability of the wound dressings. Finally, a poly (acrylic acid) (PAA) and water-based adhesive was developed and used to demonstrate the performance of the auxetic wound dressing when attached to moving body joints.

摘要

将 pH 传感器封装在伤口敷料中的好处包括对受伤皮肤的治疗监测和对慢性疾病（尤其是糖尿病患者）的早期检测。本文开发并表征了一种掺杂有 pH 指示剂苯酚红染料的 3D 打印的再入各向异性水凝胶伤口敷料。再入各向异性设计允许伤口敷料粘附在复杂的身体部位，如手臂和腿部的关节上。拉伸试验表明，其屈服强度为 140 kPa，杨氏模量为 78 MPa。此外，3D 打印水凝胶的溶胀能力高达 14%，在六天内的失重率限制在 3%，且其孔隙率接近 1.2%。获得了与人体皮肤 pH 值（4-10）相似的合理 pH 响应，并对其进行了表征。变色 pH 指示剂的集成使患者能够使用智能手机监测伤口的愈合过程。除此之外，还研究了机械性能及其对后处理的依赖性。结果表明，树脂成分和后处理的使用显著影响伤口敷料的质量和耐用性。最后，开发了一种基于聚（丙烯酸）（PAA）和水的粘合剂，并将其用于演示在附着于移动身体关节时，各向异性伤口敷料的性能。