燕麦麸增加静止期溃疡性结肠炎患者的粪便丁酸盐并预防胃肠道症状——随机对照试验
Oat Bran Increased Fecal Butyrate and Prevented Gastrointestinal Symptoms in Patients With Quiescent Ulcerative Colitis-Randomized Controlled Trial.
作者信息
Nyman Margareta, Nguyen Thao Duy, Wikman Ola, Hjortswang Henrik, Hallert Claes
机构信息
Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.
South Hospital, Stockholm, Sweden.
出版信息
Crohns Colitis 360. 2020 Feb 13;2(1):otaa005. doi: 10.1093/crocol/otaa005. eCollection 2020 Jan.
BACKGROUND
Oat bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC).
METHODS
Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat oat bran or low-fiber wheat products.
RESULTS
Ninety-four of the enrolled patients ( = 47 for both groups) completed the 24-week study. The oat bran group had significantly ( 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly ( 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets.
CONCLUSIONS
Oat bran was well tolerated when given to patients with quiescent UC.
背景
燕麦麸能特异性地提高结肠中丁酸盐的浓度，因此可能会影响溃疡性结肠炎（UC）患者的疾病进展。
方法
处于缓解期的UC患者被纳入一项对照多中心研究，并随机分为食用燕麦麸组或低纤维小麦制品组。
结果
94名入组患者（两组各47名）完成了为期24周的研究。燕麦麸组的粪便丁酸盐浓度显著更高（P<0.05），血清低密度脂蛋白水平更低，同时预防了胃肠道症状的恶化，并维持了主观健康状况。对照饮食显著增加了便秘、反流和症状负担（P<0.05），且对丁酸盐或低密度脂蛋白胆固醇没有影响。两种饮食的复发率相同。
结论
对于静止期UC患者，给予燕麦麸耐受性良好。
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