Gibbon Samuel, Breen David P, MacGillivray Thomas J
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Robert O Curle Ophthalmology Suite, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Mov Disord. 2025 Jun;40(6):1123-1133. doi: 10.1002/mds.30127. Epub 2025 Jan 30.
Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring.
We set out to investigate the relationship between optic disc pallor measured in fundoscopy images and both prevalent and incident PD.
We analyzed color fundus photographs from 787 UK Biobank participants: 89 with prevalent PD, 317 with incident PD, and 381 age- and sex-matched controls. Optic disc pallor in several zones was quantified using semi-automated software. We used logistic and linear regression, adjusted for relevant covariates, to test for associations between disc pallor and PD status and duration.
Participants with prevalent PD had significantly paler optic discs globally (OR per standard deviation [SD] increase = 1.39 [CI: 1.08-1.81], P = 0.012) and across several zones compared to controls. Each year since PD diagnosis was associated with a 1.37 SD increase in global pallor (standardized β = 1.37 [SE = 0.61], P = 0.029), and a similar increase across several zones, however, this finding was sensitive to outliers with long disease duration. No significant associations were observed for the incident PD group.
Optic disc pallor is significantly associated with PD and may become more pronounced with disease duration. This suggests that optic disc pallor, measured in routinely taken color fundus photographs, may serve as a biomarker for PD-related neurodegeneration. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
最近的研究表明，用光学相干断层扫描测量的视网膜变化在早期帕金森病（PD）中是可检测到的，这凸显了眼科生物标志物在诊断和监测方面的潜力。
我们着手研究眼底镜检查图像中测量的视盘苍白与现患和新发PD之间的关系。
我们分析了来自787名英国生物银行参与者的彩色眼底照片：89名现患PD患者、317名新发PD患者以及381名年龄和性别匹配的对照者。使用半自动软件对几个区域的视盘苍白进行量化。我们使用逻辑回归和线性回归，并对相关协变量进行调整，以检验视盘苍白与PD状态和病程之间的关联。
与对照组相比，现患PD患者的视盘在整体上（每标准差[SD]增加的比值比[OR]=1.39[置信区间：1.08 - 1.81]，P = 0.012）以及在几个区域明显更苍白。自PD诊断以来的每一年，整体苍白度增加1.37 SD（标准化β = 1.37[标准误=0.61]，P = 0.029），并且在几个区域有类似的增加，然而，这一发现对病程长的异常值敏感。在新发PD组中未观察到显著关联。
视盘苍白与PD显著相关，并且可能随着病程延长而变得更加明显。这表明，在常规拍摄的彩色眼底照片中测量的视盘苍白可能作为PD相关神经退行性变的生物标志物。© 2025作者。《运动障碍》由威利期刊有限责任公司代表国际帕金森和运动障碍协会出版。
