Luo Juanjuan, Li Ying, Zhang Tangxuan, Xv Tianhan, Chen Chao, Li Mengting, Qiu Qixiang, Song Yusheng, Wan Shaogui
Center for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, China.
China Medical University, Shenyang, China, Ganzhou, China.
Front Oncol. 2023 Jan 30;12:1092705. doi: 10.3389/fonc.2022.1092705. eCollection 2022.
Chemotherapy is widely used to treat patients with cancer. However, resistance to chemotherapeutic drugs remains a major clinical concern. The mechanisms of cancer drug resistance are extremely complex and involve such factors such as genomic instability, DNA repair, and chromothripsis. A recently emerging area of interest is extrachromosomal circular DNA (eccDNA), which forms owing to genomic instability and chromothripsis. eccDNA exists widely in physiologically healthy individuals but also arises during tumorigenesis and/or treatment as a drug resistance mechanism. In this review, we summarize the recent progress in research regarding the role of eccDNA in the development of cancer drug resistance as well as the mechanisms thereof. Furthermore, we discuss the clinical applications of eccDNA and propose some novel strategies for characterizing drug-resistant biomarkers and developing potential targeted cancer therapies.
化疗被广泛用于治疗癌症患者。然而，对化疗药物的耐药性仍然是一个主要的临床问题。癌症耐药机制极其复杂，涉及基因组不稳定、DNA修复和染色体碎裂等因素。一个最近新兴的研究领域是染色体外环状DNA（eccDNA），它由于基因组不稳定和染色体碎裂而形成。eccDNA广泛存在于生理健康个体中，但也在肿瘤发生和/或治疗过程中作为一种耐药机制出现。在本综述中，我们总结了关于eccDNA在癌症耐药性发展中的作用及其机制的最新研究进展。此外，我们讨论了eccDNA的临床应用，并提出了一些用于鉴定耐药生物标志物和开发潜在靶向癌症治疗方法的新策略。
