Wacker C D, Spiegelhalder B, Börzsönyi M, Brune G, Preussmann R
Institute of Toxicology and Chemotherapy, German Cancer Research Centre, Heidelberg.
IARC Sci Publ. 1987(84):370-4.
Introduction of 'safe' amino components into traditional accelerator molecules could be an effective measure to prevent formation of carcinogenic N-nitroso compounds during rubber production. About 20 new derivatives of the dithiocarbamate and sulfenamide class, based on 'safe' amines, were synthesized and shown to be suitable for industrial application. Some of the corresponding N-nitrosamines were prepared and investigated for mutagenicity in Salmonella typhimurium TA1535. No or weak mutagenic potential was observed in most cases. The nitrosatability of five sulfenamides derived from 'safe' amines was determined and found to be substantially lower than that of a commercial sulfenamide accelerator tested under identical conditions.
将“安全”氨基成分引入传统促进剂分子中，可能是防止橡胶生产过程中致癌性N-亚硝基化合物形成的有效措施。基于“安全”胺合成了约20种二硫代氨基甲酸盐和亚磺酰胺类的新衍生物，并证明它们适用于工业应用。制备了一些相应的N-亚硝胺，并研究了其在鼠伤寒沙门氏菌TA1535中的致突变性。在大多数情况下未观察到或仅观察到微弱的致突变潜力。测定了五种源自“安全”胺的亚磺酰胺的亚硝化能力，发现其大大低于在相同条件下测试的市售亚磺酰胺促进剂。
