Liberti Davide, Imbimbo Paola, Giustino Enrica, D'Elia Luigi, Silva Mélanie, Barreira Luísa, Monti Daria Maria
Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy.
Centre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal.
Antioxidants (Basel). 2023 Jan 31;12(2):337. doi: 10.3390/antiox12020337.
Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga (CCALA415). and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.
微藻可以成为具有不同活性的天然化合物的可靠来源。在此，我们评估了硫酸化胞外多糖（s-EPSs）和藻红蛋白（PE）的抗氧化和抗炎活性，这两种分子是红色海洋微藻（CCALA415）天然产生的。并进行了基于细胞的分析以评估这些化合物的生物活性。由于存在硫酸根，s-EPSs在永生化真核细胞系上表现出生物相容性，并且在基于细胞的系统上具有高抗氧化活性。PE在体外和基于细胞的系统上均表现出强大的抗氧化活性，但为安全使用必须进行纯化。最后，这两种分子均表现出与布洛芬相当的抗炎活性，并有助于组织再生。因此，从微藻中分离出的分子是可用于不同领域的优异抗氧化剂来源。
