CenBRAIN Neurotech, School of Engineering, Westlake University, Hangzhou 310030, China.
Biosensors (Basel). 2023 Jan 31;13(2):211. doi: 10.3390/bios13020211.
Catecholamines, including dopamine, epinephrine, and norepinephrine, are considered one of the most crucial subgroups of neurotransmitters in the central nervous system (CNS), in which they act at the brain's highest levels of mental function and play key roles in neurological disorders. Accordingly, the analysis of such catecholamines in biological samples has shown a great interest in clinical and pharmaceutical importance toward the early diagnosis of neurological diseases such as Epilepsy, Parkinson, and Alzheimer diseases. As promising routes for the real-time monitoring of catecholamine neurotransmitters, optical and electrochemical biosensors have been widely adopted and perceived as a dramatically accelerating development in the last decade. Therefore, this review aims to provide a comprehensive overview on the recent advances and main challenges in catecholamines biosensors. Particular emphasis is given to electrochemical biosensors, reviewing their sensing mechanism and the unique characteristics brought by the emergence of nanotechnology. Based on specific biosensors' performance metrics, multiple perspectives on the therapeutic use of nanomaterial for catecholamines analysis and future development trends are also summarized.
儿茶酚胺，包括多巴胺、肾上腺素和去甲肾上腺素，被认为是中枢神经系统（CNS）中最重要的神经递质亚群之一，它们在大脑的最高层次的精神功能中发挥作用，并在神经疾病中发挥关键作用。因此，对生物样本中此类儿茶酚胺的分析在临床和药物方面对早期诊断癫痫、帕金森病和阿尔茨海默病等神经疾病表现出极大的兴趣。作为实时监测儿茶酚胺神经递质的有前途的途径，光学和电化学生物传感器已被广泛采用，并被视为过去十年中急剧加速发展的领域。因此，本综述旨在全面概述儿茶酚胺生物传感器的最新进展和主要挑战。特别强调电化学生物传感器，综述了它们的传感机制以及纳米技术出现带来的独特特征。基于特定生物传感器的性能指标，还总结了纳米材料在儿茶酚胺分析中的治疗用途和未来发展趋势的多个角度。
