Department of Analytical Chemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara 06018, Turkey.
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06560, Turkey.
Biosensors (Basel). 2023 Feb 16;13(2):282. doi: 10.3390/bios13020282.
Heart failure (HF) is a cardiovascular disease defined by several symptoms that occur when the heart cannot supply the blood needed by the tissues. HF, which affects approximately 64 million people worldwide and whose incidence and prevalence are increasing, has an important place in terms of public health and healthcare costs. Therefore, developing and enhancing diagnostic and prognostic sensors is an urgent need. Using various biomarkers for this purpose is a significant breakthrough. It is possible to classify the biomarkers used in HF: associated with myocardial and vascular stretch (B-type natriuretic peptide (BNP), N-terminal proBNP and troponin), related to neurohormonal pathways (aldosterone and plasma renin activity), and associated with myocardial fibrosis and hypertrophy (soluble suppression of tumorigenicity 2 and galactin 3). There is an increasing demand for the design of fast, portable, and low-cost biosensing devices for the biomarkers related to HF. Biosensors play a significant role in early diagnosis as an alternative to time-consuming and expensive laboratory analysis. In this review, the most influential and novel biosensor applications for acute and chronic HF will be discussed in detail. These studies will be evaluated in terms of advantages, disadvantages, sensitivity, applicability, user-friendliness, etc.
心力衰竭（HF）是一种心血管疾病，其特征是当心脏无法向组织供应所需的血液时出现多种症状。HF 影响着全球约 6400 万人，其发病率和患病率正在上升，因此在公共卫生和医疗保健成本方面占有重要地位。因此，开发和增强诊断和预后传感器是当务之急。为此目的使用各种生物标志物是一个重大突破。可以对用于 HF 的生物标志物进行分类：与心肌和血管拉伸相关的（B 型利钠肽（BNP）、N 末端 proBNP 和肌钙蛋白）、与神经激素途径相关的（醛固酮和血浆肾素活性）以及与心肌纤维化和肥大相关的（可溶性肿瘤抑制因子 2 和半乳糖凝集素 3）。对于与 HF 相关的生物标志物，人们对设计快速、便携式和低成本生物传感设备的需求越来越大。生物传感器在早期诊断中作为耗时且昂贵的实验室分析的替代方法发挥着重要作用。在这篇综述中，将详细讨论用于急性和慢性 HF 的最具影响力和新颖的生物传感器应用。将根据优点、缺点、灵敏度、适用性、用户友好性等方面对这些研究进行评估。
