Department of Botany, Karnatak University, Dharwad, 580003, India.
Department of Horticultural Science, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Appl Microbiol Biotechnol. 2023 Apr;107(7-8):2061-2071. doi: 10.1007/s00253-023-12440-4. Epub 2023 Feb 27.
Since ancient times, Morinda species, particularly Morinda citrifolia, have been used for their therapeutic benefits. Iridoids, anthraquinones, coumarins, flavonoids, lignans, phytosterols, and carotenoids are examples of natural substances with bioactivity. Anthraquinone derivatives are the most significant of these chemicals since they are utilized as natural coloring agents and have a wide range of medicinal functions. Utilizing cell and organ cultures of Morinda species, various biotechnological methods have been developed for the bioproduction of anthraquinone derivatives. The generation of anthraquinone derivatives in cell and organ cultures is summarized in this article. The methods used to produce these chemicals in bioreactor cultures have also been examined. KEY POINTS: • This review investigates the potential of cell and organ cultures for anthraquinone synthesis. • The overproduction of anthraquinones has been addressed using a variety of techniques. • The use of bioreactor technologies for anthraquinone manufacturing is highlighted.
自古以来，桑科榕属植物，特别是巴戟天，因其治疗功效而被使用。具有生物活性的天然物质包括环烯醚萜类、蒽醌类、香豆素类、类黄酮、木脂素、植物甾醇和类胡萝卜素。蒽醌衍生物是这些化学物质中最重要的，因为它们被用作天然着色剂，并具有广泛的药用功能。利用桑科榕属植物的细胞和器官培养，已经开发出各种生物技术方法来生物合成蒽醌衍生物。本文总结了细胞和器官培养中蒽醌衍生物的生成。还研究了在生物反应器培养中生产这些化学物质的方法。关键点：• 本文研究了细胞和器官培养在蒽醌合成方面的潜力。• 已经使用多种技术解决了蒽醌的过量生产问题。• 强调了生物反应器技术在蒽醌制造中的应用。
