Curran J F, Yarus M
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309.
Science. 1987 Dec 11;238(4833):1545-50. doi: 10.1126/science.3685992.
Messenger RNA's are translated in successive three-nucleotide steps (a reading frame), therefore decoding must proceed in only one of three possible frames. A molecular model for correct propagation of the frame is presented based on (i) the measured translational properties of transfer RNA's (tRNA's) that contain an extra nucleotide in the anticodon loop and (ii) a straightforward concept about anticodon loop structure. The model explains the high accuracy of reading frame maintenance by normal tRNA's, as well as activities of all characterized frameshift suppressor tRNA's that have altered anticodon loops.
信使核糖核酸（mRNA）以连续的三个核苷酸步骤（一个阅读框）进行翻译，因此解码必须仅在三种可能的阅读框之一中进行。基于（i）对反密码子环中含有一个额外核苷酸的转运核糖核酸（tRNA）的测量翻译特性，以及（ii）关于反密码子环结构的一个简单概念，提出了一个阅读框正确传播的分子模型。该模型解释了正常tRNA维持阅读框的高精度，以及所有具有改变反密码子环的已表征移码抑制tRNA的活性。
