Liu Yunlan, Ren Mengjuan, Kuang Zhuoran, Luo Xufei, Li Huishan, Zhang Yikai, Wen Wanxin, Cai Yefeng, Ni Xiaojia, Chen Yaolong
School of Public Health, Lanzhou University, Lanzhou, China.
Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
Integr Med Res. 2023 Mar;12(1):100925. doi: 10.1016/j.imr.2023.100925. Epub 2023 Feb 5.
Cerebral resuscitation is one of the main therapeutic aims in the treatment of cardiac arrest (CA) patients who experience a return of spontaneous circulation (ROSC). However, the therapeutic effects of current treatments are not ideal. The purpose of this study was to evaluate the efficacy of neurological function of acupuncture combined with conventional cardiopulmonary cerebral resuscitationthe (CPCR) for patients after ROSC.
Seven electronic databases and other related websites were searched to identify studies on acupuncture combined with conventional CPCR for patients after ROSC. R software was used to conduct a meta-analysis, and the outcomes that could not be pooled were analyzed using a descriptive analysis.
Seven RCTs involving 411 participants who had experienced ROSC were eligible for inclusion. The main acupoints were (PC6), (DU26), (DU20), (KI1), and (SP6). Compared to conventional CPCR, acupuncture combined with conventional CPCR led to significantly higher Glasgow Coma Scale (GCS) scores on day 3 (mean difference (MD)=0.89, 95% CI: 0.43, 1.35, I = 0%), day 5 (MD = 1.21, 95% CI: 0.27, 2.15; I = 0%), and day 7 (MD = 1.92, 95% CI: 1.35, 2.50; I = 0%).
Acupuncture-assisted conventional CPCR may have a potential role in improving neurological function in CA patients after ROSC, but the certainty of evidence is very low and more high-quality studies are required.
This review was registered at the International Prospective Registry of Systematic Reviews (PROSPERO): CRD42021262262.
脑复苏是治疗恢复自主循环（ROSC）的心脏骤停（CA）患者的主要治疗目标之一。然而，目前治疗的效果并不理想。本研究的目的是评估针刺结合传统心肺脑复苏术（CPCR）对ROSC后患者神经功能的疗效。
检索七个电子数据库和其他相关网站，以确定针刺结合传统CPCR治疗ROSC后患者的研究。使用R软件进行荟萃分析，对无法合并的结果进行描述性分析。
七项随机对照试验（RCT）涉及411名经历过ROSC的参与者，符合纳入标准。主要穴位为内关（PC6）、百会（DU26）、素髎（DU20）、涌泉（KI1）和三阴交（SP6）。与传统CPCR相比，针刺结合传统CPCR在第3天（平均差（MD）=0.89，95%可信区间：0.43，1.35；I² = 0%）、第5天（MD = 1.21，95%可信区间：0.27，2.15；I² = 0%）和第7天（MD = 1.92，95%可信区间：1.35，2.50；I² = 0%）时格拉斯哥昏迷量表（GCS）评分显著更高。
针刺辅助传统CPCR可能在改善ROSC后CA患者的神经功能方面具有潜在作用，但证据的确定性非常低，需要更多高质量的研究。
本综述已在国际前瞻性系统评价注册库（PROSPERO）注册：CRD42021262262。
