Lee Jaeyul, Du Xiaoxi, Park Jongchan, Cui Qi, Iyer Rishyashring R, Boppart Stephen A, Gao Liang
Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, California, 90095, USA.
The authors contributed equally to this work.
Biomed Opt Express. 2023 Jan 5;14(2):627-638. doi: 10.1364/BOE.477646. eCollection 2023 Feb 1.
We present tunable image-mapping optical coherence tomography (TIM-OCT), which can provide optimized imaging performance for a given application by using a programmable phase-only spatial light modulator in a low-coherence full-field spectral-domain interferometer. The resultant system can provide either a high lateral resolution or a high axial resolution in a snapshot without moving parts. Alternatively, the system can achieve a high resolution along all dimensions through a multiple-shot acquisition. We evaluated TIM-OCT in imaging both standard targets and biological samples. Additionally, we demonstrated the integration of TIM-OCT with computational adaptive optics in correcting sample-induced optical aberrations.
我们展示了可调谐图像映射光学相干断层扫描技术（TIM-OCT），该技术通过在低相干全场光谱域干涉仪中使用可编程纯相位空间光调制器，可为特定应用提供优化的成像性能。由此产生的系统无需移动部件，就能在单次快照中提供高横向分辨率或高轴向分辨率。或者，该系统可以通过多次采集在所有维度上实现高分辨率。我们评估了TIM-OCT对标准目标和生物样本的成像效果。此外，我们展示了TIM-OCT与计算自适应光学技术相结合以校正样本引起的光学像差。
