Ho Li-Ju, Sheu Wayne Huey-Herng, Lo Su-Huey, Yeh Yen-Po, Hwu Chii-Min, Huang Chien-Ning, Hsieh Chang-Hsun, Kuo Feng-Chih
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, Republic of China.
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Diabetol Metab Syndr. 2023 Mar 8;15(1):38. doi: 10.1186/s13098-023-01018-9.
Unhealthy lifestyle has been associated with obesity and type 2 diabetes. Whereas its association with vascular complications in patients with long-duration of type 2 diabetes is still uncertain.
A total of 1188 patients with long-duration of type 2 diabetes from the Taiwan Diabetes Registry (TDR) data were analyzed. We stratified the severity of unhealthy lifestyle via scoring three factors (sleep duration <7 or >9 h, sit duration ≥ 8h, and meal numbers ≥ with night snack) and analyzed their associations with the development of vascular complications using logistic regression analysis. Besides, we also included 3285 patients with newly diagnosed type 2 diabetes as the comparison.
Increased numbers of factors that stand for unhealthy lifestyle were significantly associated with the development of cardiovascular disease, peripheral arterial occlusion disease (PAOD) and nephropathy in patients with long-duration of type 2 diabetes. After adjusting multiple covariables, having ≥ 2 factors of unhealthy lifestyle remained significant associations with cardiovascular disease and PAOD, with an odds ratio (OR) of 2.09 (95% confidence interval [CI] 1.18-3.69) and 2.68 (95% CI 1.21-5.90), respectively. Among individual factor for unhealthy lifestyle behaviors, we revealed that eating ≥ 4 meals per day with night snack increased the risk of cardiovascular disease and nephropathy after multivariable adjustment (OR of 2.60, 95% CI 1.28-5.30; OR of 2.54, 95% CI 1.52-4.26, respectively). Whereas sit duration for ≥ 8 h per day increased the risk of PAOD (OR of 4.32, 95% CI 2.38-7.84).
Unhealthy lifestyle is associated with increased prevalence of macro- and micro-vascular comorbidities in Taiwanese patients with long-duration type 2 diabetes.
不健康的生活方式与肥胖和2型糖尿病有关。然而，其与长期2型糖尿病患者血管并发症的关联仍不确定。
分析了台湾糖尿病注册（TDR）数据中1188例长期2型糖尿病患者。我们通过对三个因素（睡眠时间<7或>9小时、久坐时间≥8小时、进餐次数≥含夜宵）进行评分来分层不健康生活方式的严重程度，并使用逻辑回归分析其与血管并发症发生的关联。此外，我们还纳入了3285例新诊断的2型糖尿病患者作为对照。
代表不健康生活方式的因素数量增加与长期2型糖尿病患者心血管疾病、外周动脉闭塞性疾病（PAOD）和肾病的发生显著相关。在调整多个协变量后，具有≥2个不健康生活方式因素与心血管疾病和PAOD仍存在显著关联，优势比（OR）分别为2.09（95%置信区间[CI]1.18 - 3.69）和2.68（95%CI 1.21 - 5.90）。在不健康生活方式行为的个体因素中，我们发现多变量调整后，每天进餐≥4次且含夜宵会增加心血管疾病和肾病的风险（OR分别为2.60，95%CI 1.28 - 5.30；OR为2.54，95%CI 1.52 - 4.26）。而每天久坐时间≥8小时会增加PAOD的风险（OR为4.32，95%CI 2.38 - 7.84）。
不健康生活方式与台湾长期2型糖尿病患者大血管和微血管合并症的患病率增加有关。
