Jacobson S A, Leuchter A F, Walter D O, Weiner H
Quantitative EEG Laboratory, UCLA Neuropsychiatric Institute and Hospital.
Biol Psychiatry. 1993 Aug 1;34(3):135-40. doi: 10.1016/0006-3223(93)90382-n.
Serial quantitative electroencephalographic (QEEG) studies were performed in 33 elderly delirious, demented, and control subjects to determine which QEEG variables were associated with changes in clinical state as measured by the Folstein Mini-mental State Examination (MMSE). Conventional EEGs and brain maps were independently rated by two electroencephalographers without knowledge of clinical diagnoses. Correlational analyses were performed using these ratings, along with numerical data from QEEG. In the delirium group (n = 15), changes in scores for the relative power map and changes in relative power in the alpha band had significant associations with changes in MMSE. In the dementia group (n = 10), changes in score for absolute power maps and changes in absolute power in the delta band had significant associations with changes in MMSE. In the control group, changes in MMSE over time were negligible. These findings have potential clinical utility in diagnosing delirium, and in providing a quantitative measure of its severity, which can be used serially.
对33名老年谵妄、痴呆和对照受试者进行了系列定量脑电图（QEEG）研究，以确定哪些QEEG变量与通过Folstein简易精神状态检查表（MMSE）测量的临床状态变化相关。两名脑电图检查人员在不知道临床诊断的情况下，对常规脑电图和脑图谱进行独立评分。使用这些评分以及QEEG的数值数据进行相关分析。在谵妄组（n = 15）中，相对功率图的分数变化和α波段相对功率的变化与MMSE的变化有显著相关性。在痴呆组（n = 10）中，绝对功率图的分数变化和δ波段绝对功率的变化与MMSE的变化有显著相关性。在对照组中，MMSE随时间的变化可以忽略不计。这些发现对谵妄的诊断具有潜在的临床实用价值，并能提供其严重程度的定量测量，可进行系列使用。
