The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Front Immunol. 2023 Feb 21;14:1125253. doi: 10.3389/fimmu.2023.1125253. eCollection 2023.
Cancer vaccines have had some success in the past decade. Based on in-depth analysis of tumor antigen genomics, many therapeutic vaccines have already entered clinical trials for multiple cancers, including melanoma, lung cancer, and head and neck squamous cell carcinoma, which have demonstrated impressive tumor immunogenicity and antitumor activity. Recently, vaccines based on self-assembled nanoparticles are being actively developed as cancer treatment, and their feasibility has been confirmed in both mice and humans. In this review, we summarize recent therapeutic cancer vaccines based on self-assembled nanoparticles. We describe the basic ingredients for self-assembled nanoparticles, and how they enhance vaccine immunogenicity. We also discuss the novel design method for self-assembled nanoparticles that pose as a promising delivery platform for cancer vaccines, and the potential in combination with multiple therapeutic approaches.
过去十年中，癌症疫苗取得了一些成功。基于对肿瘤抗原基因组学的深入分析，许多治疗性疫苗已经进入多种癌症的临床试验，包括黑色素瘤、肺癌和头颈部鳞状细胞癌，这些疫苗已经显示出令人印象深刻的肿瘤免疫原性和抗肿瘤活性。最近，基于自组装纳米粒子的疫苗正在积极开发用于癌症治疗，并且在小鼠和人类中已经证实了它们的可行性。在这篇综述中，我们总结了基于自组装纳米粒子的最近的治疗性癌症疫苗。我们描述了自组装纳米粒子的基本成分，以及它们如何增强疫苗的免疫原性。我们还讨论了自组装纳米粒子的新型设计方法，它们作为癌症疫苗的有前途的递药平台，以及与多种治疗方法联合应用的潜力。
