Bond G G, Rossbacher R
Dow Chemical Company, Midland, MI 48674.
Br J Ind Med. 1993 Apr;50(4):340-8. doi: 10.1136/oem.50.4.340.
For the purpose of assessing the human carcinogenic potential of the chlorophenoxy herbicides MCPA, MCPP, and 2,4-DP, the relevant epidemiological and toxicological evidence is reviewed. These compounds have not produced tumours in animal studies conducted under current test guidelines, giving no reason to predict that they would be carcinogenic to humans. Epidemiological studies have been conducted on three continents; greater emphasis is placed on the studies reported from western Europe, however, as this has been the area of more use. Although several of these studies provide suggestive evidence of associations between exposure to chlorophenoxy compounds and increased risks for some uncommon cancers, it is inconsistent and far from conclusive. None of the evidence specifically implicates MCPA, MCPP, or 2,4-DP as human carcinogens.
为评估氯苯氧基除草剂MCPA、MCPP和2,4-DP对人类的致癌潜力，对相关的流行病学和毒理学证据进行了审查。在按照现行试验指南进行的动物研究中，这些化合物未产生肿瘤，因此没有理由预测它们会对人类致癌。在三大洲开展了流行病学研究；不过，更侧重于西欧报告的研究，因为该地区使用这些除草剂更为广泛。尽管其中几项研究提供了接触氯苯氧基化合物与某些罕见癌症风险增加之间存在关联的提示性证据，但这些证据并不一致，也远非结论性的。没有证据明确表明MCPA、MCPP或2,4-DP是人类致癌物。
