几种常见药用真菌中三萜类化合物的结构多样性、发酵生产、生物活性及应用：最新进展及未来展望。

Structural diversity, fermentation production, bioactivities and applications of triterpenoids from several common medicinal fungi: Recent advances and future perspectives.

机构信息

College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.

出版信息

Fitoterapia. 2023 Apr;166:105470. doi: 10.1016/j.fitote.2023.105470. Epub 2023 Mar 11.

DOI:10.1016/j.fitote.2023.105470

Abstract

Medicinal fungi are beneficial to human health and it reduces the risk of chronic diseases. Triterpenoids are polycyclic compounds derived from the straight-chain hydrocarbon squalene, which are widely distributed in medicinal fungi. Triterpenoids from medicinal fungal sources possess diverse bioactive activities such as anti-cancer, immunomodulatory, anti-inflammatory, anti-obesity. This review article describes the structure, fermentation production, biological activities, and application of triterpenoids from the medicinal fungi including Ganoderma lucidum, Poria cocos, Antrodia camphorata, Inonotus obliquus, Phellinus linteus, Pleurotus ostreatus, and Laetiporus sulphureus. Besides, the research perspectives of triterpenoids from medicinal fungi are also proposed. This paper provides useful guidance and reference for further research on medicinal fungi triterpenoids.

摘要

药用真菌有益于人类健康，可以降低慢性病的发病风险。三萜类化合物是一种源于直链烃鲨烯的多环化合物，广泛存在于药用真菌中。药用真菌来源的三萜类化合物具有多种生物活性，如抗癌、免疫调节、抗炎、抗肥胖等。本文综述了灵芝、茯苓、樟芝、桦褐孔菌、木蹄层孔菌、糙皮侧耳和硫磺菌等药用真菌中三萜类化合物的结构、发酵生产、生物活性和应用。此外，还提出了药用真菌三萜类化合物的研究展望。本文为药用真菌三萜类化合物的进一步研究提供了有益的指导和参考。