免疫调节在组织修复和再生中的作用。
Immunomodulation for Tissue Repair and Regeneration.
机构信息
School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea.
出版信息
Tissue Eng Regen Med. 2023 Jun;20(3):389-409. doi: 10.1007/s13770-023-00525-0. Epub 2023 Mar 15.
Abstract
Various immune cells participate in repair and regeneration following tissue injury or damage, orchestrating tissue inflammation and regeneration processes. A deeper understanding of the immune system's involvement in tissue repair and regeneration is critical for the development of successful reparatory and regenerative strategies. Here we review recent technologies that facilitate cell-based and biomaterial-based modulation of the immune systems for tissue repair and regeneration. First, we summarize the roles of various types of immune cells in tissue repair. Second, we review the principle, examples, and limitations of regulatory T (Treg) cell-based therapy, a representative cell-based immunotherapy. Finally, we discuss biomaterial-based immunotherapy strategies that aim to modulate immune cells using various biomaterials for tissue repair and regeneration.
摘要
各种免疫细胞参与组织损伤或破坏后的修复和再生，协调组织炎症和再生过程。深入了解免疫系统在组织修复和再生中的作用，对于成功开发修复和再生策略至关重要。在这里，我们回顾了最近的技术，这些技术促进了基于细胞和基于生物材料的免疫系统调节，以实现组织修复和再生。首先，我们总结了各种类型的免疫细胞在组织修复中的作用。其次，我们回顾了调节性 T（Treg）细胞为基础的治疗的原理、实例和局限性，这是一种代表性的基于细胞的免疫疗法。最后，我们讨论了基于生物材料的免疫治疗策略，这些策略旨在使用各种生物材料来调节免疫细胞，以实现组织修复和再生。
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