Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Chembiochem. 2023 Jul 3;24(13):e202200786. doi: 10.1002/cbic.202200786. Epub 2023 Jun 1.
Oceans cover 71 % of Earth's surface and are home to hundreds of thousands of species, many of which are microbial. Knowledge about marine microbes has strongly increased in the past decades due to global sampling expeditions, and hundreds of detailed studies on marine microbial ecology, physiology, and biogeochemistry. However, the translation of this knowledge into biotechnological applications or synthetic biology approaches using marine microbes has been limited so far. This review highlights key examples of marine bacteria in synthetic biology and metabolic engineering, and outlines possible future work based on the emerging marine chassis organisms Vibrio natriegens and Halomonas bluephagenesis. Furthermore, the valorization of algal polysaccharides by genetically enhanced microbes is presented as an example of the opportunities and challenges associated with blue biotechnology. Finally, new roles for marine synthetic biology in tackling pressing global challenges, including climate change and marine pollution, are discussed.
海洋覆盖了地球表面的 71%，是数十万种生物的家园，其中许多是微生物。由于全球采样考察，以及数百项关于海洋微生物生态学、生理学和生物地球化学的详细研究，过去几十年来，人们对海洋微生物的了解大大增加。然而，到目前为止，这些知识在生物技术应用或使用海洋微生物的合成生物学方法方面的转化一直受到限制。这篇综述重点介绍了海洋细菌在合成生物学和代谢工程中的关键实例，并根据新兴的海洋底盘生物盐沼盐单胞菌和海蓝菌属蓝细菌，概述了未来可能开展的工作。此外，通过基因增强微生物对藻类多糖的增值利用，作为与蓝色生物技术相关的机会和挑战的一个例子。最后，讨论了海洋合成生物学在应对紧迫的全球挑战（包括气候变化和海洋污染）方面的新作用。
