Department for Small Animal Internal Medicine, Clinic for Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Joint Microbiome Facility of the Medical University of Vienna, University of Vienna, Vienna, Austria.
Sci Rep. 2023 Mar 16;13(1):4337. doi: 10.1038/s41598-023-31024-w.
The role of the gut microbiome in developing Inflammatory Bowel Disease (IBD) in humans and dogs has received attention in recent years. Evidence suggests that IBD is associated with alterations in gut microbial composition, but further research is needed in veterinary medicine. The impact of IBD treatment on the gut microbiome needs to be better understood, especially in a breed-specific form of IBD in Yorkshire Terriers known as Yorkshire Terrier Enteropathy (YTE). This study aimed to investigate the difference in gut microbiome composition between YTE dogs during disease and remission and healthy Yorkshire Terriers. Our results showed a significant increase in specific taxa such as Clostridium sensu stricto 1, Escherichia-Shigella, and Streptococcus, and a decrease in Bacteroides, Prevotella, Alloprevotella, and Phascolarctobacterium in YTE dogs compared to healthy controls. No significant difference was found between the microbiome of dogs in remission and those with active disease, suggesting that the gut microbiome is affected beyond clinical recovery.
近年来，人们越来越关注肠道微生物组在人类和犬类炎症性肠病 (IBD) 发展中的作用。有证据表明，IBD 与肠道微生物组成的改变有关，但兽医领域还需要进一步的研究。IBD 治疗对肠道微生物组的影响需要更好地理解，特别是在约克夏梗特有的 IBD 形式——约克夏梗肠病 (YTE) 中。本研究旨在调查 YTE 犬在疾病活动期和缓解期与健康约克夏梗之间肠道微生物组组成的差异。我们的研究结果表明，与健康对照组相比，YTE 犬中特定分类群（如严格梭菌 1、大肠杆菌-志贺氏菌和链球菌）显著增加，而拟杆菌、普雷沃氏菌、Alloprevotella 和 Phascolarctobacterium 减少。缓解期犬和活动期犬的微生物组之间没有发现显著差异，这表明肠道微生物组在临床恢复之外受到影响。
