特定非编码RNA在非小细胞肺癌生物学中的作用。

The role of selected non-coding RNAs in the biology of non-small cell lung cancer.

作者信息

Kiełbowski Kajetan, Ptaszyński Konrad, Wójcik Janusz, Wojtyś Małgorzata Edyta

机构信息

Department of Thoracic Surgery and Transplantation, Pomeranian Medical University, Szczecin, Poland.

Department of Pathology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland.

出版信息

Adv Med Sci. 2023 Mar;68(1):121-137. doi: 10.1016/j.advms.2023.02.004. Epub 2023 Mar 16.

DOI:10.1016/j.advms.2023.02.004

PMID:36933328

Abstract

Lung cancer is the second most frequently diagnosed cancer worldwide and a leading cause of cancer-related deaths. Non-small cell lung carcinoma (NSCLC) represents 85% of all cases. Accumulating evidence highlights the outstanding role of non-coding RNA (ncRNA) in regulating the tumorigenesis process by modulating crucial signaling pathways. Micro RNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA) are either up- or downregulated in lung cancer patients and can promote or suppress the progression of the disease. These molecules interact with messenger RNA (mRNA) and with each other to regulate gene expression and stimulate proto-oncogenes or silence tumor suppressors. NcRNAs provide a new strategy to diagnose or treat lung cancer patients and multiple molecules have already been identified as potential biomarkers or therapeutic targets. The aim of this review is to summarize the current evidence on the roles of miRNA, lncRNA and circRNA in NSCLC biology and present their clinical potential.

摘要

肺癌是全球第二常见的确诊癌症，也是癌症相关死亡的主要原因。非小细胞肺癌（NSCLC）占所有病例的85%。越来越多的证据表明，非编码RNA（ncRNA）通过调节关键信号通路在肿瘤发生过程中发挥着重要作用。微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）在肺癌患者中要么上调要么下调，并且可以促进或抑制疾病进展。这些分子与信使RNA（mRNA）相互作用并彼此相互作用，以调节基因表达并激活原癌基因或使肿瘤抑制基因沉默。NcRNAs为诊断或治疗肺癌患者提供了一种新策略，并且多种分子已被确定为潜在的生物标志物或治疗靶点。本综述的目的是总结关于miRNA、lncRNA和circRNA在NSCLC生物学中的作用的当前证据，并展示它们的临床潜力。