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建模埃博拉幸存者污名化对疾病传播动力学的影响。

Modelling the impact of stigmatisation of Ebola survivors on the disease transmission dynamics.

机构信息

Department of Mathematics and Applied Mathematics, University of Johannesburg, Auckland Park Campus, Johannesburg, 2006, South Africa.

出版信息

Sci Rep. 2023 Mar 24;13(1):4859. doi: 10.1038/s41598-023-32040-6.

DOI:10.1038/s41598-023-32040-6
PMID:36964196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10039084/
Abstract

Ebola virus disease (EVD) is one of the most highly stigmatised diseases in any affected country because of the disease's high infectivity and case fatality rate. Infected individuals and most especially survivors are often stigmatised by their communities for fear of contagion. We propose and analyse a mathematical model to examine the impact of stigmatisation of Ebola survivors on the disease dynamics. The model captures both the internal stigmatisation experienced by infected individuals after witnessing survivors being stigmatised and the external stigmatisation imposed on survivors by their communities. The results obtained from our analysis and simulations show that both internal and external stigma may lead to an increase in the burden of Ebola virus disease by sustaining the number of infected individuals who hide their infection and the number of unsafe burials of deceased Ebola victims. Strategies that seek to put an end to both forms of stigmatisation and promote safe burials will therefore go a long way in averting the EVD burden.

摘要

埃博拉病毒病(EVD)是受影响国家中最具污名化的疾病之一,因为该疾病具有很高的传染性和病死率。受感染的个人,尤其是幸存者,往往因担心被传染而受到社区的污名化。我们提出并分析了一个数学模型,以研究对埃博拉幸存者的污名化对疾病动态的影响。该模型既捕捉了感染者在目睹幸存者被污名化后所经历的内在污名化,也捕捉了社区对幸存者施加的外在污名化。我们的分析和模拟结果表明,内在和外在的污名都可能导致埃博拉病毒病负担增加,因为这会维持那些隐瞒感染的感染者数量,以及不安全埋葬埃博拉死者的数量。因此,寻求消除这两种污名化形式并促进安全埋葬的策略,将有助于减轻埃博拉病毒病的负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/7ca50f0ec9a1/41598_2023_32040_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/b14f36e77e57/41598_2023_32040_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/fa09a9de3938/41598_2023_32040_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/7e498ed76f08/41598_2023_32040_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/b0d94484f4cc/41598_2023_32040_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/4e356f514a03/41598_2023_32040_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/ec71bf081912/41598_2023_32040_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/aa57bfa9f12a/41598_2023_32040_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/7ca50f0ec9a1/41598_2023_32040_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/b14f36e77e57/41598_2023_32040_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/fa09a9de3938/41598_2023_32040_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/7e498ed76f08/41598_2023_32040_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/b0d94484f4cc/41598_2023_32040_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/4e356f514a03/41598_2023_32040_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/ec71bf081912/41598_2023_32040_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/aa57bfa9f12a/41598_2023_32040_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/10039084/7ca50f0ec9a1/41598_2023_32040_Fig8_HTML.jpg

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Comput Math Methods Med. 2022 May 13;2022:4150043. doi: 10.1155/2022/4150043. eCollection 2022.
2
Transmission models indicate Ebola virus persistence in non-human primate populations is unlikely.传播模型表明,埃博拉病毒在非人类灵长类动物群体中持续存在的可能性不大。
J R Soc Interface. 2022 Feb;19(187):20210638. doi: 10.1098/rsif.2021.0638. Epub 2022 Feb 2.
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An Ebola virus disease model with fear and environmental transmission dynamics.
一种具有恐惧和环境传播动力学的埃博拉病毒病模型。
Infect Dis Model. 2021 Mar 20;6:545-559. doi: 10.1016/j.idm.2021.03.002. eCollection 2021.
4
Modelling the daily risk of Ebola in the presence and absence of a potential vaccine.在有和没有潜在疫苗的情况下对埃博拉病毒的每日风险进行建模。
Infect Dis Model. 2020;5:905-917. doi: 10.1016/j.idm.2020.10.003. Epub 2020 Oct 15.
5
Post-Ebola psychosocial experiences and coping mechanisms among Ebola survivors: a systematic review.埃博拉幸存者的埃博拉后心理社会经历和应对机制:系统评价。
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Ebola virus disease-related stigma among survivors declined in Liberia over an 18-month, post-outbreak period: An observational cohort study.埃博拉病毒病相关耻辱感在利比里亚幸存者中下降:一项观察性队列研究。
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Stigma and Ebola survivorship in Liberia: Results from a longitudinal cohort study.利比里亚的污名化和埃博拉幸存者:一项纵向队列研究的结果。
PLoS One. 2018 Nov 28;13(11):e0206595. doi: 10.1371/journal.pone.0206595. eCollection 2018.
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Care of Ebola Survivors and Factors Associated With Clinical Sequelae-Monrovia, Liberia.利比里亚蒙罗维亚埃博拉幸存者的护理及与临床后遗症相关的因素
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Mobile health clinic for the medical management of clinical sequelae experienced by survivors of the 2013-2016 Ebola virus disease outbreak in Sierra Leone, West Africa.西非塞拉利昂 2013-2016 年埃博拉病毒病疫情幸存者临床后遗症医疗管理的移动医疗诊所。
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'Once there is life, there is hope' Ebola survivors' experiences, behaviours and attitudes in Sierra Leone, 2015.“留得青山在,不怕没柴烧”:2015年塞拉利昂埃博拉幸存者的经历、行为与态度
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