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用于3D打印应用的含金属添加剂的可生物降解聚合物(聚乳酸)杀菌性能的初步研究

Preliminary Study of the Bactericide Properties of Biodegradable Polymers (PLA) with Metal Additives for 3D Printing Applications.

作者信息

López-Camacho Anyul, Magaña-García Dulce, Grande María José, Carazo-Álvarez Daniel, La Rubia M Dolores

机构信息

Chemical, Environmental and Materials Engineering Department, University of Jaén, 23071 Jaén, Spain.

Smart Materials 3D, Polígono Industrial El Retamar, 7, 23680 Jaén, Spain.

出版信息

Bioengineering (Basel). 2023 Feb 27;10(3):297. doi: 10.3390/bioengineering10030297.

Abstract

Plastic is a highly used material in various sectors. Due to its plentiful availability in the environment, microorganism surface contamination is a risk. The aim of this work is to achieve bactericidal capacity in plastics that reduces the microorganism's colonization risk and, consequently, reduces the chances of having an infection with and bacteria. Using polylactic acid (PLA) as the polymeric matrix, mixtures in concentrations of metal additive of ions of silver (Ag) R148 and S254 in 1% and 2% have been studied and manufactured. The materials are developed on an industrial scale through a process that proceeds as follows: (I) a mixture of polymer and additive in a double-screw compounder to obtain the compound in different concentrations, (II) the manufacture of filaments with a single-screw extruder, (III) 3D printing parts. Therefore, materials are evaluated in the form of powder, pellets and printed pieces to ensure their antibacterial effectiveness throughout the manufacturing process. The results of the research show antibacterial effectiveness for and of metal additives and polymeric compounds for all manufacturing phases on an industrial scale, with the effectiveness for additive R148 predominating at a concentration of 2%, demonstrating its microbial efficacy on surfaces with potential application in medicine.

摘要

塑料是各领域广泛使用的材料。由于其在环境中大量存在,微生物表面污染存在风险。这项工作的目的是使塑料具备杀菌能力,降低微生物定植风险,从而减少感染[具体细菌名称缺失]和[具体细菌名称缺失]细菌的几率。以聚乳酸(PLA)作为聚合物基体,研究并制备了金属添加剂银(Ag)离子R148和S254浓度为1%和2%的混合物。这些材料通过以下流程在工业规模上开发:(I)在双螺杆混炼机中混合聚合物和添加剂以获得不同浓度的复合物,(II)用单螺杆挤出机制备长丝,(III)3D打印部件。因此,对材料以粉末、颗粒和打印件的形式进行评估,以确保其在整个制造过程中的抗菌有效性。研究结果表明,在工业规模的所有制造阶段,金属添加剂和聚合物化合物对[具体细菌名称缺失]和[具体细菌名称缺失]均具有抗菌有效性,添加剂R148在浓度为2%时效果最佳,证明了其在具有医学潜在应用的表面上的微生物功效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97de/10045209/d74fa778b5c7/bioengineering-10-00297-g001.jpg

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