Warwick W J, Huang N N, Waring W W, Cherian A G, Brown I, Stejskal-Lorenz E, Yeung W H, Duhon G, Hill J G, Strominger D
Clin Chem. 1986 May;32(5):850-3.
A new sweat test (CF Indicator; Medtronic, Inc.) for cystic fibrosis (CF) features a compact, portable configuration of electrodes that dispense pilocarpine for iontophoresis. A disposable chloride sensor patch absorbs a specified volume of sweat, in which the chloride concentration is immediately determined as less than 40, 40-60, or greater than 60 mmol/L. We assessed the performance of the system in a five-center study, in relation to the clinical diagnosis and to the Gibson-Cooke sweat test (GCST) as a control test. With sweat chloride concentrations of less than or equal to 40 mmol/L defined as normal and greater than 40 mmol/L as indicating persons at risk for CF, the new system showed 91% specificity and 100% sensitivity for CF, as compared with 92.8% and 100%, respectively, for the GCST. When we used sweat chloride concentrations of less than or equal to 60 mmol/L as probably normal and greater than 60 mmol/L as probably indicative of CF, the new system showed a 99.1% specificity and 98.6% sensitivity, vs 97.8% specificity and 97.9% sensitivity for the GCST test. In both procedures, occasionally insufficient sweat was collected, and this appeared related to the age of the subject. We conclude that the new sweat test system is potentially useful in physicians' offices, in clinics, and similar settings.
一种用于囊性纤维化（CF）的新型汗液检测（CF指标；美敦力公司）具有紧凑、便携的电极配置，可用于离子电渗疗法的毛果芸香碱给药。一次性氯化物传感器贴片吸收特定体积的汗液，其中氯化物浓度可立即测定为低于40、40 - 60或高于60 mmol/L。我们在一项五中心研究中评估了该系统的性能，将其与临床诊断以及作为对照检测的吉布森 - 库克汗液检测（GCST）进行比较。以汗液氯化物浓度小于或等于40 mmol/L定义为正常，大于40 mmol/L表示有患CF风险的人群，新系统对CF的特异性为91%，敏感性为100%，而GCST的特异性和敏感性分别为92.8%和100%。当我们将汗液氯化物浓度小于或等于60 mmol/L视为可能正常，大于60 mmol/L视为可能指示CF时，新系统的特异性为99.1%，敏感性为98.6%，而GCST检测的特异性为97.8%，敏感性为97.9%。在这两种检测过程中，偶尔会收集到不足的汗液，这似乎与受试者的年龄有关。我们得出结论，这种新型汗液检测系统在医生办公室、诊所及类似场所可能会很有用。
