采用可持续方法原位形成银纳米颗粒制备水凝胶复合材料

Preparation of Hydrogel Composites Using a Sustainable Approach for In Situ Silver Nanoparticles Formation.

作者信息

Chronopoulou Laura, Binaymotlagh Roya, Cerra Sara, Haghighi Farid Hajareh, Di Domenico Enea Gino, Sivori Francesca, Fratoddi Ilaria, Mignardi Silvano, Palocci Cleofe

机构信息

Department of Chemistry, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

Research Center for Applied Sciences to the Safeguard of Environment and Cultural Heritage (CIABC), Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

出版信息

Materials (Basel). 2023 Mar 7;16(6):2134. doi: 10.3390/ma16062134.

DOI:10.3390/ma16062134

PMID:36984014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10056655/

Abstract

The recognized antibacterial properties of silver nanoparticles (AgNPs) characterize them as attractive nanomaterials for developing new bioactive materials less prone to the development of antibiotic resistance. In this work, we developed new composites based on self-assembling Fmoc-Phe3 peptide hydrogels impregnated with in situ prepared AgNPs. Different methodologies, from traditional to innovative and eco-sustainable, were compared. The obtained composites were characterized from a hydrodynamic, structural, and morphological point of view, using different techniques such as DLS, SEM, and rheological measurements to evaluate how the choice of the reducing agent determines the characteristics of AgNPs and how their presence within the hydrogel affects their structure and properties. Moreover, the antibacterial properties of these composites were tested against , a major human pathogen responsible for a wide range of clinical infections. Results demonstrated that the hydrogel composites containing AgNPs (hgel@AgNPs) could represent promising biomaterials for treating -related infections.

摘要

银纳米颗粒（AgNPs）公认的抗菌特性使其成为开发不易产生抗生素耐药性的新型生物活性材料的有吸引力的纳米材料。在这项工作中，我们基于自组装的Fmoc-Phe3肽水凝胶开发了新的复合材料，其中浸渍了原位制备的AgNPs。比较了从传统到创新以及生态可持续的不同方法。从流体动力学、结构和形态学角度对所得复合材料进行了表征，使用了不同技术，如动态光散射（DLS）、扫描电子显微镜（SEM）和流变学测量，以评估还原剂的选择如何决定AgNPs的特性，以及它们在水凝胶中的存在如何影响其结构和性能。此外，测试了这些复合材料对一种导致广泛临床感染的主要人类病原体的抗菌性能。结果表明，含有AgNPs的水凝胶复合材料（hgel@AgNPs）可能是治疗相关感染的有前景的生物材料。