Du Jiahao, Shi Ping, Fang Fanfu, Yu Hongliu
Institute of Rehabilitation Engineering and Technology, University of Shanghai for Science and Technology, Shanghai, China.
Department of Rehabilitation Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Front Neurosci. 2023 Mar 15;17:1136820. doi: 10.3389/fnins.2023.1136820. eCollection 2023.
Establishing an accurate way to quantify pain is one of the most formidable tasks in neuroscience and medical practice. Functional near-infrared spectroscopy (fNIRS) can be utilized to detect the brain's reaction to pain. The study sought to assess the neural mechanisms of the wrist-ankle acupuncture transcutaneous electrical nerve stimulation analgesic bracelet () in providing pain relief and altering cerebral blood volume dynamics, and to ascertain the reliability of cortical activation patterns as a means of objectively measuring pain.
The participants (mean age 36.6 ± 7.2 years) with the cervical-shoulder syndrome (CSS) underwent pain testing prior to, 1 min following, and 30 min after the left point Jianyu treatment. The was used to administer an electrical stimulation therapy that lasted for 5 min. A 24-channel fNIRS system was utilized to monitor brain oxyhemoglobin (HbO) levels, and changes in HbO concentrations, cortical activation areas, and subjective pain assessment scales were documented.
We discovered that HbO concentrations in the prefrontal cortex significantly increased when CSS patients were exposed to painful stimuli at the cerebral cortex level. The second pain test saw a considerable decrease in the average HbO change amount in the prefrontal cortex when was applied, which in turn led to a reduction in the amount of activation and the size of the activated area in the cortex.
This study revealed that the frontal polar (FP) and dorsolateral prefrontal cortex (DLPFC) were linked to the analgesic modulation activated by the .
建立一种准确量化疼痛的方法是神经科学和医学实践中最艰巨的任务之一。功能性近红外光谱（fNIRS）可用于检测大脑对疼痛的反应。本研究旨在评估腕踝针经皮电神经刺激镇痛手环在缓解疼痛和改变脑血容量动态方面的神经机制，并确定皮层激活模式作为客观测量疼痛手段的可靠性。
患有颈肩综合征（CSS）的参与者（平均年龄36.6±7.2岁）在左侧肩髃穴治疗前、治疗后1分钟和治疗后30分钟接受疼痛测试。使用该手环进行持续5分钟的电刺激治疗。采用24通道fNIRS系统监测脑氧合血红蛋白（HbO）水平，并记录HbO浓度变化、皮层激活区域和主观疼痛评估量表。
我们发现，当CSS患者在大脑皮层水平受到疼痛刺激时，前额叶皮层的HbO浓度显著增加。在进行手环治疗时，第二次疼痛测试中前额叶皮层的平均HbO变化量显著降低，这反过来导致皮层激活量和激活区域大小的减少。
本研究表明，额极（FP）和背外侧前额叶皮层（DLPFC）与该手环激活的镇痛调节有关。
