用于癌症疫苗佐剂开发的材料工程策略。
Materials engineering strategies for cancer vaccine adjuvant development.
作者信息
Zhang Xuanbo, Yang Bowei, Ni Qianqian, Chen Xiaoyuan
机构信息
Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore 119074, Singapore.
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China.
出版信息
Chem Soc Rev. 2023 May 9;52(9):2886-2910. doi: 10.1039/d2cs00647b.
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy. Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the immune response. The success of adjuvants in achieving stable, safe, and immunogenic cancer vaccines has generated enthusiasm for adjuvant development. Specifically, advances in materials science are providing insights into the rational design of vaccine adjuvants for topical cancer immunotherapy. Here, we outline the current state of materials engineering strategies, including those based on molecular adjuvants, polymers/lipids, inorganic nanoparticles, and bio-derived materials, for adjuvant development. We also elaborate on how these engineering strategies and the physicochemical features of the materials involved influence the effects of adjuvants.
癌症疫苗已成为癌症免疫治疗的一种强大新工具。佐剂是增强免疫反应强度、速度和持续时间的疫苗成分。佐剂在实现稳定、安全且具有免疫原性的癌症疫苗方面取得的成功激发了人们对佐剂研发的热情。具体而言，材料科学的进展为局部癌症免疫治疗用疫苗佐剂的合理设计提供了思路。在此，我们概述了用于佐剂研发的材料工程策略的现状，包括基于分子佐剂、聚合物/脂质、无机纳米颗粒和生物衍生材料的策略。我们还详细阐述了这些工程策略以及所涉及材料的物理化学特性如何影响佐剂的效果。
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