Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Expert Opin Drug Deliv. 2021 Jul;18(7):949-977. doi: 10.1080/17425247.2021.1888926. Epub 2021 Apr 1.
: Today, the development of multifunctional nanoplatforms is more seriously considered in the field of cancer theranostics.: In this respect, nanoparticles provide several advantages over the routine, conventional diagnostic methods, and treatments. Due to the expedient properties of iron oxide nanoparticles, such as being readily modified, great payload potential, intrinsic magnetic qualification, considerable biocompatibility, and overwhelming response to targeting strategies, these nanoparticles can be considered good candidates for application as diagnostic contrast agents and drug/gene delivery vehicles, while also being incorporated into hyperthermia-based approaches. Interestingly, these agents are detectable with routine imaging modalities such as magnetic resonance imaging.: Therefore, combining the traditional diagnostics and therapies with nanotechnological approaches may leave a positive impact on the survival rate of patients with cancer. This review summarizes the application of magnetic iron oxide nanoparticles in both and models of brain tumors.
: 如今，多功能纳米平台的发展在癌症治疗诊断领域受到了更多的关注。: 在这方面，与常规的传统诊断方法和治疗相比，纳米粒子具有许多优势。由于氧化铁纳米粒子具有易于修饰、高载药潜力、固有磁性、相当的生物相容性以及对靶向策略的强烈响应等便利特性，这些纳米粒子可被视为作为诊断对比剂和药物/基因传递载体的良好候选物，同时也可被纳入基于热疗的方法。有趣的是，这些试剂可以通过磁共振成像等常规成像方式进行检测。: 因此，将传统的诊断和治疗方法与纳米技术方法相结合，可能会对癌症患者的生存率产生积极影响。本综述总结了磁性氧化铁纳米粒子在脑肿瘤的 和 模型中的应用。
